miRNA Delivery by Nanosystems: State of the Art and Perspectives

被引：47
作者：
Moraes, Fernanda C. [1 ]
Pichon, Chantal [2 ]
Letourneur, Didier [1 ]
Chaubet, Frederic [1 ]
机构：
[1] Univ Paris, Univ Sorbonne Paris Nord, LVTS, INSERM U1148, F-75018 Paris, France
[2] Univ Orleans, Ctr Biophys Mol, CNRS, UPR4301, F-45071 Orleans, France
来源：
PHARMACEUTICS | 2021年 / 13卷 / 11期
关键词：
miRNA delivery; non-viral vectors; nanoparticles; NEGATIVE BREAST-CANCER; NANOPARTICLE-MEDIATED DELIVERY; SOLID LIPID NANOPARTICLES; CO-DELIVERY; MICRORNA DELIVERY; SIRNA DELIVERY; IN-VITRO; CHITOSAN NANOPARTICLES; TARGETED DELIVERY; PLASMID DNA;
D O I：
10.3390/pharmaceutics13111901
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
MicroRNAs (miRNAs) are short (~21-23 nucleotides), non-coding endogenous RNA molecules that modulate gene expression at the post-transcriptional level via the endogenous RNA interference machinery of the cell. They have emerged as potential biopharmaceuticals candidates for the treatment of various diseases, including cancer, cardiovascular and metabolic diseases. However, in order to advance miRNAs therapeutics into clinical settings, their delivery remains a major challenge. Different types of vectors have been investigated to allow the delivery of miRNA in the diseased tissue. In particular, non-viral delivery systems have shown important advantages such as versatility, low cost, easy fabrication and low immunogenicity. Here, we present a general overview of the main types of non-viral vectors developed for miRNA delivery, with their advantages, limitations and future perspectives.
引用
收藏
页数：20
相关论文
共 148 条
  • [71] The emerging role of the piRNA/piwi complex in cancer
    Liu, Yongmei
    Dou, Mei
    Song, Xuxia
    Dong, Yanhan
    Liu, Si
    Liu, Haoran
    Tao, Jiaping
    Li, Wenjing
    Yin, Xunhua
    Xu, Wenhua
    [J]. MOLECULAR CANCER, 2019, 18 (01)
  • [72] Development of a novel cationic liposome: Evaluation of liposome mediated transfection and anti-proliferative effects of miR-101 in acute myeloid leukemia
    Lotfabadi, Narges Nikoonahad
    Kouchesfehani, Homa Mohseni
    Sheikhha, Mohammad Hasan
    Kalantar, Seyed Mehdi
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2018, 45 : 196 - 202
  • [73] Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injury
    Louw, Andrew M.
    Kolar, Mallappa K.
    Novikova, Liudmila N.
    Kingham, Paul J.
    Wiberg, Mikael
    Kjems, Jorgen
    Novikov, Lev N.
    [J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 12 (03) : 643 - 653
  • [74] Modulating the Growth and Imatinib Sensitivity of Chronic Myeloid Leukemia Stem/Progenitor Cells with Pullulan/MicroRNA Nanoparticles In Vitro
    Ma, Wenjuan
    Liu, Jian
    Xie, Jundan
    Zhang, Xiuyan
    Zhou, Haixia
    Yao, Hong
    Zhang, Weiqi
    Guo, Dawei
    Zhu, Lingying
    Xiao, Lun
    Wu, Depei
    Xu, Haiyan
    Chen, Suning
    Zhao, Yun
    [J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2015, 11 (11) : 1961 - 1974
  • [75] Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy
    Mansouri, S
    Lavigne, P
    Corsi, K
    Benderdour, M
    Beaumont, E
    Fernandes, JC
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) : 1 - 8
  • [76] Amphipathic chitosans improve the physicochemical properties of siRNA-chitosan nanoparticles at physiological conditions
    Martins, Grazieli Olinda
    Petronio, Maicon Segalla
    Furuyama Lima, Aline Margarete
    Martinez Junior, Andre Miguel
    de Oliveira Tiera, Vera Aparecida
    Calmon, Marilia de Freitas
    Leite Vilamaior, Patricia Simone
    Han, Sang Won
    Tiera, Marcio Jose
    [J]. CARBOHYDRATE POLYMERS, 2019, 216 : 332 - 342
  • [77] Chitosan-Based Nanoparticles for Mucosal Delivery of RNAi Therapeutics
    Martirosyan, Alina
    Olesen, Morten Jarlstad
    Howard, Kenneth A.
    [J]. NONVIRAL VECTORS FOR GENE THERAPY LIPID- AND POLYMER-BASED GENE TRANSFER, 2014, 88 : 325 - 352
  • [78] Non-coding RNAs as drug targets
    Matsui, Masayuki
    Corey, David R.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (03) : 167 - 179
  • [79] Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
    Merkel, Olivia M.
    Librizzi, Damiano
    Pfestroff, Andreas
    Schurrat, Tino
    Buyens, Kevin
    Sanders, Niek N.
    De Smedt, Stefaan C.
    Behe, Martin
    Kissel, Thomas
    [J]. JOURNAL OF CONTROLLED RELEASE, 2009, 138 (02) : 148 - 159
  • [80] P-selectin targeting polysaccharide-based nanogels for miRNA delivery
    Moraes, Fernanda C.
    Ramirez, Laura Marcelo Forero
    Aid, Rachida
    Benadda, Samira
    Maire, Murielle
    Chauvierre, Cedric
    Antunes, Joana C.
    Chaubet, Frederic
    Letourneur, Didier
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 597
3456789101112