Muscle fatigue from losing your PHD

被引：2

作者：

Dang, Chi V. ^{[1
]}

Gao, Ping ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Hematol, Baltimore, MD 21205 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2008.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2 alpha- and PPAR alpha-dependent fashion.

引用

页码：191 / 192

页数：2

共 11 条

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