Advancing the knowledge of surfaces and protein interactions is paramount to development of non-fouling membranes for many applications, particularly continuous blood flow wearable and implantable devices. Here, highly controlled experiments to understand the effect of graphene oxide (GO) surface properties on its protein adsorption are presented. A newly developed self-assembly process is implemented to build a GO membrane with an atomically smooth surface to eliminate the effect of surface roughness on protein adsorption. The GO oxidation level is varied to change the overall membrane hydrophilicity while the nanoplatelets size and edge area is maintained constant. The fouling characteristics of the membrane are examined through scanning electron microscope imaging and long-term water flux measurements. These measurements unambiguously prove that proteins are primarily adsorbed on the basal areas of nanoplatelets, on the graphitic regions, away from the nanoplatelets edges. As a result, while decreasing the oxidation level reduced the overall surface hydrophilicity leading to more protein adsorption, the membrane mass flux is minimally impacted. Studies on a polymer membrane under similar conditions show expansion of protein agglomerates over time leading to formation of large biofilm domains, while the GO nanoplatelets edges function as a barrier to formation of an expansive biofilm.
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School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, United StatesSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, United States
机构:
Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Wang, Tao
Wang, Jin
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Adm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Wang, Jin
Zhao, Zhenzhen
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Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Zhao, Zhenzhen
Zheng, Xi
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Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Zheng, Xi
Li, Jiding
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Tsinghua Univ, State Key Lab Chem Engn, Dept Chem Engn, Beijing 100084, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Li, Jiding
Liu, Helei
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Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
Liu, Helei
Zhao, Zhiping
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Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R ChinaAdm Comm Wuhan East Lake High Tech Dev Zone, Wuhan 430075, Peoples R China
机构:
China Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R ChinaChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
Ai, Jing
Yang, Lian
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Beijing Engn Res Ctr Wastewater Reuse, Beijing 100124, Peoples R ChinaChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
Yang, Lian
Liao, Guiying
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China Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R ChinaChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
Liao, Guiying
Xia, Hua
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China Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R ChinaChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
Xia, Hua
Xiao, Feng
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Chinese Acad Sci, Res Ctr Eco Environm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R ChinaChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China