Molecular cloning of two novel rab genes from human melanocytes

被引：43

作者：

Chen, D

Guo, JR

Miki, T

Tachibana, M

Gahl, WA

机构：

[1] NICHHD,HUMAN BIOCHEM GENET SECT,HERITABLE DISORDERS BRANCH,NIH,BETHESDA,MD 20892

[2] NCI,CELLULAR & MOL BIOL LAB,NIH,BETHESDA,MD 20892

[3] NIH,NATL INST DEAFNESS & OTHER COMMUN DISORDERS,MOL GENET LAB,BETHESDA,MD 20892

来源：

GENE | 1996年 / 174卷 / 01期

关键词：

GTPase; melanosome; dense body; lysosome; vesicles; membranes;

D O I：

10.1016/0378-1119(96)00509-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We isolated the genes of two small GTP-binding proteins of the rab family from a human melanocyte cDNA library and from melanoma cells. One gene, rab30 codes for a novel rab protein of 203 amino acids with minimal homology to previously documented GTPases. The other, rab22b, appears to be an isoform of the human homologue of canine rab22. Both rab mRNAs displayed a nearly ubiquitous pattern of expression in the various tissues examined. Rab22b and rab30 were mapped to chromosomes 18 and 11, respectively.

引用

收藏

页码：129 / 134

页数：6

相关论文

共 19 条

[1] CLONING OF A RAB3 ISOTYPE PREDOMINATELY EXPRESSED IN ADIPOCYTES [J].

BALDINI, G ;

HOHL, T ;

LIN, HY ;

LODISH, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :5049-5052

[2] Alternative mRNA splicing of the novel GTPase rab28 generates isoforms with different C-termini [J].

Brauers, A ;

Schurmann, A ;

Massmann, S ;

MuhlZurbes, P ;

Becker, W ;

Kainulainen, H ;

Lie, CC ;

Joost, HG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 237 (03) :833-840

[3]

DRIVAS GT, 1991, ONCOGENE, V6, P3

[4] THE RAS SUPERFAMILY OF GTP-BINDING PROTEINS - GUIDELINES ON NOMENCLATURE [J].

KAHN, RA ;

DER, CJ ;

BOKOCH, GM .

FASEB JOURNAL, 1992, 6 (08) :2512-2513

[5] MOLECULAR-CLONING OF A CDNA-ENCODING A NOVEL SMALL GTP-BINDING PROTEIN [J].

KODA, T ;

KAKINUMA, M .

FEBS LETTERS, 1993, 328 (1-2) :21-24

[6] THE SCANNING MODEL FOR TRANSLATION - AN UPDATE [J].

KOZAK, M .

JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :229-241

[7] RAB17, A NOVEL SMALL GTPASE, IS SPECIFIC FOR EPITHELIAL-CELLS AND IS INDUCED DURING CELL POLARIZATION [J].

LUTCKE, A ;

JANSSON, S ;

PARTON, RG ;

CHAVRIER, P ;

VALENCIA, A ;

HUBER, LA ;

LEHTONEN, E ;

ZERIAL, M .

JOURNAL OF CELL BIOLOGY, 1993, 121 (03) :553-564

[8]

MIKI T, 1993, METHODS MOL GENETICS, V1, P3

[9] THE PROTEIN CD63 IS IN PLATELET DENSE GRANULES, IS DEFICIENT IN A PATIENT WITH HERMANSKY-PUDLAK SYNDROME, AND APPEARS IDENTICAL TO GRANULOPHYSIN [J].

NISHIBORI, M ;

CHAM, B ;

MCNICOL, A ;

SHALEV, A ;

JAIN, N ;

GERRARD, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1775-1782

[10] FRIENDS AND FAMILY - THE ROLE OF THE RAB GTPASES IN VESICULAR TRAFFIC [J].

NOVICK, P ;

BRENNWALD, P .

CELL, 1993, 75 (04) :597-601