Antioxidant and Antiatherogenic Properties of Phenolic Acid and Flavonol Fractions of Fruits of 'Amari' and 'Hallawi' Date (Phoenix dactylifera L.) Varieties

被引：31

作者：

Borochov-Neori, Hamutal ^{[1
]}

Judeinstein, Sylvie ^{[1
]}

Greenberg, Amnon ^{[1
]}

Volkova, Nina ^{[2
,3
]}

Rosenblat, Mira ^{[2
,3
]}

Aviram, Michael ^{[2
,3
]}

机构：

[1] Southern Arava Res & Dev, IL-88820 Mp Hevel Eilot, Israel

[2] Technion Israel Inst Technol, Rambam Med Ctr, Rappaport Fac Med, Lipid Res Lab, IL-31096 Haifa, Israel

[3] Technion Israel Inst Technol, Rambam Med Ctr, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2015年 / 63卷 / 12期

关键词：

antiatherogenic; antioxidants; date fruit; flavonols; phenolic acids; Phoenix dactylifera L; ANTI-ATHEROGENIC PROPERTIES; LDL OXIDATION; LIPOPROTEIN; EXTRACT; POLYPHENOLS; CONSUMPTION; EFFLUX; JUICE;

D O I：

10.1021/jf506094r

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Date (Phoenix dactylifera L.) fruit phenolic-acid or flavonol fractions were examined in vitro for antioxidant and antiatherogenic properties. Two fractions of each subgroup were prepared from two date varieties, 'Amari' and 'Hallawi', by solid phase extraction on C18. The fractions were analyzed for phenolics composition by RP-HPLC and tested for ferric-reducing antioxidant power, free radical scavenging capacity, inhibition of Cu2+-induced LDL oxidation, and enhancement of HDL-mediated cholesterol efflux from macrophages. All four fractions exhibited variable capacities to reduce ferric ions, scavenge radicals, and inhibit LDL oxidation. Flavonol fractions were considerably better inhibitors of LDL oxidation compared to phenolic acid fractions, with IC50's of 9-31 nmol GAE mL(-1) compared to 85-116 nmol GAE mL(-1), respectively. Only the flavonol fractions stimulated cholesterol removal from macrophages. Within each subgroup, the levels of all the activities varied with fraction composition. The results demonstrated strong structure-activity relationships for date phenolics and identified date flavonols as potential antiatherogenic bioactives.

引用

页码：3189 / 3195

页数：7

共 42 条

[1] Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman [J].

Al-Farsi, M ;

Alasalvar, C ;

Morris, A ;

Baron, M ;

Shahidi, F .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (19) :7592-7599

[2] Antioxidant and Nutritional Properties of Date Fruit from Elche Grove as Affected by Maturation and Phenotypic Variability of Date Palm [J].

Amoros, A. ;

Pretel, M. T. ;

Almansa, M. S. ;

Botella, M. A. ;

Zapata, P. J. ;

Serrano, M. .

FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL, 2009, 15 (01) :65-72

[3]

Aviram M, 2005, HANDB EXP PHARM, V170, P263

[4] PLASMA-LIPOPROTEIN SEPARATION BY DISCONTINUOUS DENSITY GRADIENT ULTRA-CENTRIFUGATION IN HYPERLIPOPROTEINEMIC PATIENTS [J].

AVIRAM, M .

BIOCHEMICAL MEDICINE, 1983, 30 (01) :111-118

[5] Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation [J].

Aviram, M ;

Rosenblat, M ;

Gaitini, D ;

Nitecki, S ;

Hoffman, A ;

Dornfeld, L ;

Volkova, N ;

Presser, D ;

Attias, J ;

Liker, H ;

Hayek, T .

CLINICAL NUTRITION, 2004, 23 (03) :423-433

[6]

Barreveld W. H., 1993, AGR SERVICES B

[7] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].

Benzie, IFF ;

Strain, JJ .

ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76

[8] Phenolic Antioxidants and Antiatherogenic Effects of Marula (Sclerocarrya birrea Subsp caffra) Fruit Juice in Healthy Humans [J].

Borochov-Neori, Hamutal ;

Judeinstein, Sylvie ;

Greenberg, Amnon ;

Fuhrman, Bianca ;

Attias, Judith ;

Volkova, Nina ;

Hayek, Tony ;

Aviram, Michael .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (21) :9884-9891

[9] Date (Phoenix dactylifera L.) Fruit Soluble Phenolics Composition and Anti-atherogenic Properties in Nine Israeli Varieties [J].

Borochov-Neori, Hamutal ;

Judeinstein, Sylvie ;

Greenberg, Amnon ;

Volkova, Nina ;

Rosenblat, Mira ;

Aviram, Michael .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2013, 61 (18) :4278-4286

[10]

Brown JE, 1998, BIOCHEM J, V330, P1173

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