Bone marrow microenvironment of MPN cells

被引:1
作者
Malara, Alessandro [1 ]
Di Buduo, Christian A. [1 ]
Abbonante, Vittorio [1 ]
Balduini, Alessandra [1 ]
机构
[1] Univ Pavia, Dept Mol Med, Pavia, Italy
来源
CELLULAR AND MOLECULAR ASPECTS OF MYELOPROLIFERATIVE NEOPLASMS - PT A | 2021年 / 365卷
关键词
MESENCHYMAL STROMAL CELLS; HEMATOPOIETIC STEM-CELLS; MYELOPROLIFERATIVE NEOPLASMS; TGF-BETA; EXTRACELLULAR-MATRIX; PRIMARY MYELOFIBROSIS; MEGAKARYOCYTES CONTRIBUTE; IDIOPATHIC MYELOFIBROSIS; LEUKEMIC TRANSFORMATION; MORPHOGENETIC PROTEINS;
D O I
10.1016/bs.ircmb.2021.07.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this chapter, we will discuss the current knowledge concerning the alterations of the cellular components in the bone marrow niche in Myeloproliferative Neoplasms (MPNs), highlighting the central role of the megakaryocytes in MPN progression, and the extracellular matrix components characterizing the fibrotic bone marrow.
引用
收藏
页码:71 / 96
页数:26
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