A novel one-step synthesis of 2-substituted 6-azaindoles from 3-amino-4-picoline and carboxylic esters

被引：22

作者：

Song, JJ ^{[1
]}

Tan, ZL ^{[1
]}

Gallou, F ^{[1
]}

Xu, JH ^{[1
]}

Yee, NK ^{[1
]}

Senanayake, CH ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Chem Dev, Ridgefield, CT 06877 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 16期

关键词：

D O I：

10.1021/jo0506480

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dilithiation of 3-amino-4-picoline (1) was achieved with sec-BuLi at room temperature. Condensation of the resulting dianion (2) with carboxylic esters afforded a wide range of 2-substituted 6-azaindoles in good yields.

引用

页码：6512 / 6514

页数：3

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