Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature)

被引：30

作者：

Smolarz, Beata ^{[1
]}

Makowska, Marianna ^{[2
,3
,4
]}

Romanowicz, Hanna ^{[1
]}

机构：

[1] Polish Mothers Mem Hosp Res Inst, Dept Pathol, Lab Canc Genet, Rzgowska 281-289, PL-93338 Lodz, Poland

[2] Charite Univ Med Berlin, Dept Anesthesiol & Intens Care Med, Augustenburger Pl 1, D-13353 Berlin, Germany

[3] Free Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany

[4] Humboldt Univ, Augustenburger Pl 1, D-13353 Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 21期

关键词：

pharmacogenetics; drug-resistant epilepsy; genes; CYP2; family; MDR-1; GABA receptors; ion channels; BLOOD-BRAIN-BARRIER; FRONTAL-LOBE EPILEPSY; PARTIAL-ONSET SEIZURES; RECEPTOR-1 POLYMORPHISM G1465A; MIGRATING PARTIAL SEIZURES; STEVENS-JOHNSON SYNDROME; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; DOUBLE-BLIND; MDR1; GENE;

D O I：

10.3390/ijms222111696

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to assess the control of seizures and side effects of antiepileptic drugs. Candidate genes encode proteins involved in pharmacokinetic processes (drug transporters, metabolizing enzymes), pharmacodynamic processes (receptors, ion channels, enzymes, regulatory proteins, secondary messengers) and drug hypersensitivity (immune factors). This article provides an overview of the literature on the influence of genetic factors on treatment in epilepsy.

引用

页数：17

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