Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response

被引：17

作者：

Wu, Guoxin ^{[1
]}

Zuck, Paul ^{[1
]}

Goh, Shih Lin ^{[1
]}

Milush, Jeffrey M. ^{[2
]}

Vohra, Poonam ^{[3
]}

Wong, Joseph K. ^{[4
,5
]}

Somsouk, Ma ^{[6
]}

Yukl, Steven A. ^{[4
,5
]}

Shacklett, Barbara L. ^{[7
]}

Chomont, Nicolas ^{[8
]}

Haase, Ashley T. ^{[9
]}

Hatano, Hiroyu ^{[10
]}

Schacker, Timothy W. ^{[11
]}

Deeks, Steven G. ^{[10
]}

Hazuda, Daria J. ^{[1
]}

Hunt, Peter W. ^{[2
]}

Howell, Bonnie J. ^{[1
]}

机构：

[1] Merck & Co Inc, Kenilworth, NJ USA

[2] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Div Pathol & Lab Med, San Francisco, CA 94143 USA

[4] San Francisco Vet Affairs Hlth Care Syst, Dept Med, Div Infect Dis, San Francisco, CA USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp, Dept Med, Div Gastroenterol, San Francisco, CA USA

[7] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

[8] Univ Montreal, Infectiol & Immunol & Ctr Rech Chum, Dept Microbiol, Montreal, PQ, Canada

[9] Univ Minnesota, Dept Microbiol & Immunol, Sch Med, Minneapolis, MN USA

[10] Univ Calif San Francisco, Dept Med, Div HIV ID & Global Med, San Francisco, CA USA

[11] Univ Minnesota, Dept Med, Div Infect Dis, Minneapolis, MN USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 224卷 / 09期

关键词：

HIV; gag p24; lymph nodes; rectal biopsy; fine needle aspirates; biomarker; HIV persistence; PERSISTENCE; ACTIVATION; BLOOD; DNA;

D O I：

10.1093/infdis/jiab121

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4(+) T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8(+) T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

引用

页码：1593 / 1598

页数：6

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