Clinical significance of the ratio between FOXP3 positive regulatory T cell and interleukin-17 secreting cell in renal allograft biopsies with acute T-cell-mediated rejection

被引：47

作者：

Chung, Byung H. ^{[2
,3
,4
]}

Oh, Hye J.

Piao, Shang G. ^{[2
,3
]}

Hwang, Hyeon S. ^{[3
,4
]}

Sun, In O. ^{[3
,4
]}

Choi, Sun R. ^{[3
,4
]}

Park, Hoon S. ^{[3
,4
]}

Choi, Bum S. ^{[3
,4
]}

Choi, Yeong J. ^{[5
]}

Park, Cheol W. ^{[3
,4
]}

Kim, Yong-Soo ^{[3
,4
]}

Cho, Mi-La ^{[1
,2
]}

Yang, Chul W. ^{[2
,3
,4
]}

机构：

[1] Catholic Univ Korea, Coll Med, Catholic Inst Med Sci, Rheumatism Res Ctr,Dept Internal Med, Seoul 137040, South Korea

[2] Catholic Univ Korea, Coll Med, Convergent Res Consortium Immunol Dis, Seoul 137040, South Korea

[3] Catholic Univ Korea, Coll Med, Transplant Res Ctr, Seoul 137040, South Korea

[4] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, Seoul 137040, South Korea

[5] Catholic Univ Korea, Coll Med, Dept Pathol, Seoul 137040, South Korea

来源：

IMMUNOLOGY | 2012年 / 136卷 / 03期

关键词：

acute T-cell-mediated rejection; FOXP3; interleukin-17; regulatory T cell; T helper type 17; TRANSPLANT GLOMERULOPATHY; T(H)17 CELLS; TH17; EXPRESSION; DIAGNOSIS; INTERPLAY; PATHWAY; DISEASE; IL-17;

D O I：

10.1111/j.1365-2567.2012.03588.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study is to investigate the clinical significance of the ratio between interleukin-17 (IL-17) secreting cell and FOXP3-positive regulatory T cell (FOXP3+ Treg) infiltration in renal allograft tissues with acute T-cell-mediated rejection (ATCMR). Fifty-six patients with biopsy-proven ATCMR were included. Infiltration of FOXP3+ Treg and IL-17-secreting cells was evaluated with immunostaining for FOXP3 or IL-17 on the biopsy specimens, and the patients were divided into the FOXP3 high group (Log FOXP3/IL-17 > 0.45) or the IL-17 high group (Log FOXP3/IL-17 < 0.45). We compared the allograft function, severity of tissue injury, and clinical outcome between the two groups. In the IL-17 high group, allograft function was significantly decreased compared with the FOXP3 high group (P < 0.05). The severity of interstitial and tubular injury in the IL-17 high group was higher than the FOXP3 high group (P < 0.05). The proportions of steroid-resistant rejection, incomplete recovery and recurrent ATCMR were higher in the IL-17 high group than in the FOXP3 high group (all indicators, P < 0.05). The IL-17 high group showed lower 1-year (54% versus 90%, P < 0.05) and 5-year (38% versus 85%, P < 0.05) allograft survival rates compared with the FOXP3 high group. Multivariate analysis revealed that the FOXP3/IL-17 ratio was a significant predictor for allograft outcome. The FOXP3/IL-17 ratio is a useful indicator for representing the severity of tissue injury, allograft dysfunction and for predicting the clinical outcome of ATCMR.

引用

页码：344 / 351

页数：8

共 36 条

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