rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains

被引：80
作者：
Beckert, Patrick
Hillemann, Doris [1 ]
Kohl, Thomas A. [2 ]
Kalinowski, Joern [2 ]
Richter, Elvira [1 ]
Niemann, Stefan
Feuerriegel, Silke [1 ]
机构：
[1] Res Ctr Borstel, Natl Reference Ctr Mycobacteria, Borstel, Germany
[2] Univ Bielefeld, Ctr Biotechnol, Inst Genome Res & Syst Biol, D-33615 Bielefeld, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 05期
关键词：
OXAZOLIDINONES; MECHANISM;
D O I：
10.1128/AAC.06227-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistant Mycobacterium tuberculosis strains. Next-generation sequencing confirmed rplC T460C as the sole mutation in an LZD-resistant M. tuberculosis H37Rv strain selected in vitro. Sequencing analysis revealed the rplC T460C mutation in eight further LZD-resistant isolates (three in vitro-selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n = 84).
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收藏
页码：2743 / 2745
页数：3
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