The link between epigenetics, pain sensitivity and chronic pain

被引：9

作者：

Giordano, Rocco ^{[1
]}

Petersen, Kristian Kjaer-Staal ^{[1
,2
]}

Arendt-Nielsen, Lars ^{[1
,2
,3
]}

机构：

[1] Aalborg Univ, Fac Med, Ctr Neuroplast & Pain CNAP, Ctr Sensory Motor Interact SMI,Dept Hlth Sci & Te, Fredrik Bajers Vej 7,D3, DK-9220 Aalborg, Denmark

[2] Aalborg Univ, Fac Engn & Sci, Ctr Math Modeling Knee Osteoarthrit MathKOA, Dept Mat & Prod, Aalborg, Denmark

[3] Aalborg Univ Hosp, Dept Med Gastroenterol, Mech Sense, Aalborg, Denmark

来源：

SCANDINAVIAN JOURNAL OF PAIN | 2022年 / 22卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

epigenetic modifications; epigenetic of pain; microRNA; CHRONIC POSTOPERATIVE PAIN; NEUROPATHIC PAIN; KNEE OSTEOARTHRITIS; DNA METHYLATION; EXPRESSION; MICRORNAS;

D O I：

10.1515/sjpain-2022-0086

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Increasing evidence suggests an association between gene expression and clinical pain. Epigenetic modifications are the main modulators of gene expression or protein translation in response to environmental stimuli and pathophysiological conditions. Preclinical and clinical studies indicate that epigenetic modifications could also impact the development of pain, the transition from acute to chronic pain, and the maintenance hereof.

引用

收藏

页码：664 / 666

页数：3

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