Serum Levels of α-Klotho Are Correlated with Cerebrospinal Fluid Levels and Predict Measures of Cognitive Function

被引：30

作者：

Kundu, Payel ^{[1
]}

Zimmerman, Benjamin ^{[1
,2
,3
]}

Quinn, Joseph F. ^{[4
,5
]}

Kaye, Jeffrey ^{[4
]}

Mattek, Nora ^{[4
]}

Westaway, Shawn K. ^{[4
]}

Raber, Jacob ^{[1
,4
,6
,7
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, L470,3181SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97239 USA

[3] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA

[4] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA

[5] Vet Affairs Med Ctr, Dept Neurol, Portland, OR USA

[6] Oregon Hlth & Sci Univ, Dept Psychiat, Div Neurosci, ONPRC, Portland, OR 97239 USA

[7] Oregon Hlth & Sci Univ, Dept Radiat Med, Div Neurosci, ONPRC, Portland, OR 97239 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 86卷 / 03期

关键词：

alpha-klotho; apoE; cerebrospinal fluid; Clinical Dementia Rating; Mini-Mental State Examination; serum; APOLIPOPROTEIN-E APOE; ALZHEIMERS-DISEASE; SEX-DIFFERENCES; POLYMORPHISM; MORTALITY; DEMENTIA; PLASMA; ADULTS; GENE; TAU;

D O I：

10.3233/JAD-215719

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: alpha-klotho might play a role in neurodegenerative diseases. Objective: To determine levels of alpha-klotho and apoE in serum and cerebrospinal fluid (CSF) samples and their relationship with the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). Methods: All subjects were between age 39 to 83+ (n = 94). CDR and MMSE were administered to all participants. CSF was collected in the early afternoon by lumbar puncture. Results: Serum and CSF levels of alpha-klotho are positively correlated and both predict scores on the MMSE and CDR, regardless of sex or apoE4 status. Conclusion: Our results demonstrate that alpha-klotho may be an important biomarker of cognitive health and neurodegeneration, and that relatively non-invasive sampling of alpha-klotho from serum is likely highly reflective of CSF levels.

引用

收藏

页码：1471 / +

页数：14

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