Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

被引：540

作者：

Duan, Tianhao ^{[1
]}

Du, Yang ^{[1
]}

Xing, Changsheng ^{[1
]}

Wang, Helen Y. Y. ^{[1
,2
]}

Wang, Rong-Fu ^{[1
,2
,3
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA USA

[2] Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dept Pediat, Los Angeles, CA USA

[3] Univ Southern California, Norris Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

toll-like receptors; cell-mediated immunity; T cells; signaling pathway; infectious diseases; autoimmune diseases; cancer; NF-KAPPA-B; REGULATORY T-CELLS; PATTERN-RECOGNITION RECEPTORS; SINGLE-STRANDED RNA; PLASMACYTOID DENDRITIC CELLS; SYNCYTIAL VIRUS-INFECTION; LINEAR UBIQUITIN CHAINS; HEAT-SHOCK PROTEINS; CUTTING EDGE; I INTERFERON;

D O I：

10.3389/fimmu.2022.812774

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of innate immune responses. Since their discovery, TLRs have revolutionized the field of immunology by filling the gap between the initial recognition of pathogens by innate immune cells and the activation of the adaptive immune response. TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can directly regulate the T cell activation, growth, differentiation, development, and function under diverse physiological conditions. This review provides an overview of TLR signaling pathways and their regulators and discusses how TLR signaling, directly and indirectly, regulates cell-mediated immunity. In addition, we also discuss how TLR signaling is critically important in the host's defense against infectious diseases, autoimmune diseases, and cancer.

引用

页数：22

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