Histologic coagulative tumour necrosis as a prognostic indicator of aggressiveness in renal, lung, thyroid and colorectal carcinomas: A brief review

被引：42
作者：
Caruso, Rosario [1 ]
Parisi, Antonino [2 ]
Bonanno, Anna [1 ]
Paparo, Domenica [2 ]
Quattrocchi, Emilia [1 ]
Branca, Giovanni [1 ]
Scardigno, Marco [1 ]
Fedele, Francesco [1 ]
机构：
[1] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy
[2] Univ Messina, Dept Surg Sci, I-98125 Messina, Italy
来源：
ONCOLOGY LETTERS | 2012年 / 3卷 / 01期
关键词：
tumour necrosis; histopathology; Prognosis; POORLY DIFFERENTIATED CARCINOMA; CELL CARCINOMA; CANCER;
D O I：
10.3892/ol.2011.420
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumour growth involves two essential deviations from the normal state including the induction of proliferative stimuli, and simultaneous suppression of potentially compensatory cell death. It has been suggested that the development of invasive cancer involves a progressive switch from predominantly apoptotic to necrotic tumour cell death. The presence of tumour necrosis in pathologic specimens may not only reflect tumour biology, but also provide additional beneficial prognostic information. This review emphasises the role of tumour necrosis as an additional prognostic factor for patients with certain types of epithelial neoplasms.
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页码：16 / 18
页数：3
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