Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats

被引：34

作者：

Watanabe-Kamiyama, Mari ^{[1
]}

Kamiyama, Shin ^{[1
,2
]}

Horiuchi, Kimiko ^{[1
]}

Ohinata, Kousaku ^{[1
,3
]}

Shirakawa, Hitoshi ^{[1
]}

Furukawa, Yuji ^{[1
]}

Komai, Michio ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Dept Sci Food Funct & Hlth, Lab Nutr,Aoba Ku, Sendai, Miyagi 9818555, Japan

[2] Soka Univ, Dept Bioinformat, Cell Biol Lab, Tokyo, Japan

[3] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Kyoto, Japan

来源：

BRITISH JOURNAL OF NUTRITION | 2008年 / 99卷 / 04期

关键词：

biotin; hypertension; stroke; soluble guanylate cyclase;

D O I：

10.1017/S0007114507841122

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Biotin is a member of the vitamin B-complex family. Biotin deficiency has been associated with hyperglycaemia and insulin resistance in animals and humans. In the present study, we investigated the pharmacological effects of biotin on hypertension in the stroke-prone spontaneously hypertensive rat (SHRSP) strain. We observed that long-term administration of biotin decreased systolic blood pressure in the SHRSP strain; also, a single dose of biotin immediately decreased systolic blood pressure in this strain. Pretreatment with the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazole [4,3-alpha]quinoxalin-1-one abolished the hypotensive action of biotin in the SHRSP strain, while pretreatment with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester had no effect on the action of biotin. Biotin reduced coronary arterial thickening and the incidence of stroke in the SHRSP strain. These results suggest that the pharmacological dose of biotin decreased the blood pressure of the SHRSP via an NO-independent direct activation of soluble guanylate cyclase. Our findings reveal the beneficial effects of biotin on hypertension and the incidence of stroke.

引用

页码：756 / 763

页数：8

共 34 条

[1] Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats [J].