Synthesis and characterization of 159Gd-doped hydroxyapatite nanorods for bioapplications as theranostic systems

被引：55

作者：

Cipreste, Marcelo F. ^{[1
]}

Peres, Anderson M. ^{[1
]}

Cotta, Alexandre A. C. ^{[1
]}

Aragon, Fermin H. ^{[1
]}

Antunes, Alan de M. ^{[1
]}

Leal, Alexandre S. ^{[1
]}

Macedo, Waldemar A. A. ^{[1
]}

de Sousa, Edesia M. B. ^{[1
]}

机构：

[1] CDTN, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2016年 / 181卷

关键词：

Hydroxyapatite nanorods; Gadolinium; Neutron activation; Theranostic system; DRUG-DELIVERY; MESOPOROUS HYDROXYAPATITE; BIOMEDICAL APPLICATIONS; PHOSPHORUS SOURCE; CONTRAST AGENT; NANOPARTICLES; MORPHOLOGY; CANCER; MRI; TOXICITY;

D O I：

10.1016/j.matchemphys.2016.06.063

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Gadolinium-doped hydroxyapatite (HA-Gd) nanorods have become promisor theranostic nanoparticles for early stage cancers as radioisotope carriers able to act in the treatment and multi-imaging diagnosis by single photon emission computed tomography and magnetic resonance imaging systems. In this work, gadolinium-doped HA nanorods were synthesized aiming the use as theranostic system for osteosarcomas. The as-prepared HA-Gd nanorods were characterized by XRD with Rietveld refinement method, FTIR, XPS, ICP-AES, TEM, SEM, BET and VSM in order to investigate the physical -chemical, morphology, pore size distribution and magnetic properties. Moreover, phosphorous and gadolinium in the HA-Gd sample were activated by neutron capture, in a nuclear reactor, producing P-32 and Gd-159 radioisotopes, and the surfaces of these nanorods were functionalized with folic acid. The results indicate that Gd3+ are trapped in the HA nanorods crystal net showing great stability of the HA-Gd interaction. Gadolinium provide paramagnetic properties on HA nanorods and structural phosphorous and gadolinium can be activated to induced gamma and beta activity. The well succeeded production of Gd-159-P-32-HA makes this material a promisor agent to act as a theranostic system. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：301 / 311

页数：11

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