Metal-Free Syntheses of α-Ketothioamide and α-Ketoamide Derivatives from Sulfoxonium Ylides

被引：34

作者：

Chaubey, Trayambek Nath ^{[1
]}

Borpatra, Paran J. ^{[1
]}

Sharma, Ajay ^{[1
]}

Pandey, Satyendra Kumar ^{[1
]}

机构：

[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 43期

关键词：

WILLGERODT-KINDLER REACTION; METHYL KETONES; C-H; OXIDATIVE SYNTHESIS; AMINES; INHIBITORS; ACTIVATION; SULFUR; ARYLGLYOXALS; FORMAMIDES;

D O I：

10.1021/acs.orglett.2c03371

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient base, additive and metal-free synthetic methods for alpha-ketothioamide and alpha-ketoamide derivatives from readily available sulfoxonium ylides have been described. Sulfoxonium ylides with primary or secondary amines afforded alpha-ketothioamides in the presence of elemental sulfur, whereas alpha-ketoamides were produced when I2 and TBHP were present. The reaction proceeded well at room temperature and generated the corresponding molecules in good to excellent yields. The reaction can be scaled-up and tolerated by a range of functional groups with simple operational procedures.

引用

页码：8062 / 8066

页数：5

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