K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa

被引：24

作者：

Zhang, H ^{[1
]}

Nordenskjöld, B

Dufmats, M

Söderkvist, P

Sun, XF

机构：

[1] Linkoping Univ, Dept Biomed & Surg, Div Cell Biol, S-58185 Linkoping, Sweden

[2] Linkoping Univ, Dept Biomed & Surg, Div Oncol, S-58185 Linkoping, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 1998年 / 34卷 / 13期

关键词：

K-ras; transitional mucosa; mucinous carcinomas; colorectal cancer; allele-specific PCR;

D O I：

10.1016/S0959-8049(98)00283-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The K-ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa (n=106), transitional mucosa (n=69) and tumours (n=149) from 149 patients with colorectal adenocarcinomas. K-ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, bat not in the normal mucosa. Further, mutation rates were increased in younger patients (P=0.001) and in mucinous carcinomas (50%) compared with well differentiated (17%), moderately differentiated (26%) or poorly differentiated (24%) tumours. Our findings indicate that mucinous carcinoma may represent a distinct genetic entity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2053 / 2057

页数：5

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