Mechanics of epithelial tissues during gap closure

被引：96
作者：
Begnaud, Simon [1 ,2 ]
Chen, Tianchi [3 ]
Delacour, Delphine [1 ,2 ]
Mege, Rene-Marc [1 ,2 ]
Ladoux, Benoit [1 ,2 ,3 ]
机构：
[1] CNRS, UMR 7592, IJM, Paris, France
[2] Univ Paris Diderot, Paris, France
[3] Natl Univ Singapore, Mechanobiol Inst MBI, Singapore, Singapore
来源：
CURRENT OPINION IN CELL BIOLOGY | 2016年 / 42卷
基金：
欧洲研究理事会;
关键词：
COLLECTIVE CELL-MIGRATION; STRING WOUND CLOSURE; NEURAL-TUBE CLOSURE; DORSAL CLOSURE; LEADER CELLS; LEADING-EDGE; SINGLE-CELL; E-CADHERIN; SIGNALING PATHWAYS; DROSOPHILA EMBRYOS;
D O I：
10.1016/j.ceb.2016.04.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based contractile cables and/or protrusive activity of cells lining the gap. This review discusses the relative contributions of 'pursestring' and cell crawling mechanisms regulated by cell-substrate and cell-cell interactions, cellular mechanics and physical constraints from the environment.
引用
收藏
页码：52 / 62
页数：11
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