Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis, and Their Inhibitory Effects on Nitric Oxide Production

被引：24

作者：

Wu, Wen ^{[1
,2
]}

Zhao, Feng ^{[3
]}

Ding, Rong ^{[2
]}

Bao, Li ^{[1
]}

Gao, Hao ^{[4
]}

Lu, Jin-Cai ^{[2
]}

Yao, Xin-Sheng ^{[4
]}

Zhang, Xiao-Qing ^{[1
]}

Liu, Hong-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100090, Peoples R China

[2] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[3] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[4] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2011年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

ISOCITRIC ACID; VOLVATUS; RELEASE;

D O I：

10.1002/cbdv.201000184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new drimane-type sesquiterpenoid ethers of isocitric acid, named cryptoporic acids J-M, were isolated from the fruiting bodies of Cryptoporus sinensis, together with six known cryptoporic acids. Their structures were elucidated on the basis of extensive spectroscopic analyses. Among them, cryptoporic acid D showed strong inhibition against nitric oxide (NO) production in macrophages with an IC(50) of 45.8 +/- 3.6 mu m, comparable to the positive control of hydrocortisone (IC(50) of 40.6 +/- 2.5 mu m).

引用

页码：1529 / 1538

页数：10

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