Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study

被引：11

作者：

Li, Ge-Fei ^{[1
,2
]}

Ban, Shiyu ^{[3
,4
]}

Wang, Mengxing ^{[3
,4
]}

Zhang, Jilei ^{[3
,4
]}

Lu, Haifeng ^{[3
,4
]}

Shi, Yan-Hui ^{[1
,2
]}

He, Xin-Wei ^{[1
,2
]}

Wu, Yi-Lan ^{[1
,2
]}

Peng, Peng ^{[1
]}

Liu, Yi-Sheng ^{[1
]}

Zhuang, Mei-Ting ^{[1
]}

Zhao, Rong ^{[1
,2
]}

Shen, Xiao-Lei ^{[1
]}

Li, Qiang ^{[1
]}

Liu, Jian-Ren ^{[1
,2
]}

Du, Xiaoxia ^{[3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Neurol, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Clin Res Ctr, Sch Med, Shanghai, Peoples R China

[3] East China Normal Univ, Sch Phys & Mat Sci, Shanghai Key Lab Magnet Resonance, Shanghai, Peoples R China

[4] East China Normal Univ, Sch Phys & Mat Sci, Dept Phys, Shanghai, Peoples R China

来源：

PLOS ONE | 2018年 / 13卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MAJOR DEPRESSIVE DISORDER; CORTICAL ACTIVITY; SPASTICITY; METAANALYSIS; MODULATION; DYSTONIA; STROKE;

D O I：

10.1371/journal.pone.0207448

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understood. Methodology/Principal findings Herein, we investigated brain functions in 9 patients who received illegal cosmetic injections of botulinum and 18 matched controls by combining the analysis methods of regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI. Compared with the controls, the patients with botulism exhibited significantly reduced ReHo values in the left posterior lobe of the cerebellum extending to the right anterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum extending to the para-hippocampal gyrus and right posterior lobe of the cerebellum. The patients with botulism also showed weakened ALFF values in the right anterior lobe of the cerebellum extending to the left anterior lobe of the cerebellum and right posterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum. Conclusions/Significance The results indicate that BoNT-A may modulate cerebral activation in specific areas, which may play roles in both the adverse effects of botulism and the mechanism underlying clinical treatment with BoNT-A.

引用

页数：12

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