Peptides for Therapy and Diagnosis of Alzheimer's Disease

被引：2

作者：

Funke, Susanne Aileen ^{[1
]}

Willbold, Dieter ^{[1
,2
]}

机构：

[1] Forschungszentrum Julich, D-52425 Julich, Germany

[2] Univ Dusseldorf, Inst Phys Biol, D-40225 Dusseldorf, Germany

来源：

CURRENT PHARMACEUTICAL DESIGN | 2012年 / 18卷 / 06期

关键词：

Alzheimer's disease; amyloid-beta; therapy; diagnosis; peptides; AMYLOID-BETA-PEPTIDE; IMAGE PHAGE DISPLAY; I MIMETIC PEPTIDES; FIBRIL FORMATION; MOUSE MODEL; APOLIPOPROTEIN-E; TAU HYPERPHOSPHORYLATION; NEUROFIBRILLARY TANGLES; COGNITIVE FUNCTION; LEARNING-DEFICITS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with devastating effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are available. Additionally, AD can be diagnosed with certainty only post mortem, whereas the diagnosis "probable AD" can be established earliest when severe clinical symptoms appear. Specific neuropathological changes like neurofibrillary tangles and amyloid plaques define AD. Amyloid plaques are mainly composed of the amyloid-beta peptide (A beta). Several lines of evidence suggest that the progressive concentration and subsequent aggregation and accumulation of A beta play a fundamental role in the disease progress. Therefore, substances which bind to A beta and influence aggregation thereof are of great interest. An enormous number of organic substances for therapeutic purposes are described. This review focuses on peptides developed for diagnosis and therapy of AD and discusses the pre- and disadvantages of peptide drugs.

引用

页码：755 / 767

页数：13

共 137 条

[81] Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid β peptide and inhibit Aβ-induced toxicity [J].

McLaurin, J ;

Golomb, R ;

Jurewicz, A ;

Antel, JP ;

Fraser, PE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (24) :18495-18502

[82] The peptide KLVFF-K6 promotes β-amyloid(1-40) protofibril growth by association but does not alter protofibril effects on cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) [J].

Moss, MA ;

Nichols, MR ;

Reed, DK ;

Hoh, JH ;

Rosenberry, TL .

MOLECULAR PHARMACOLOGY, 2003, 64 (05) :1160-1168

[83] Combining Independent Drug Classes into Superior, Synergistically Acting Hybrid Molecules [J].

Mueller-Schiffmann, Andreas ;

Maerz-Berberich, Julia ;

Andreyeva, Aksana ;

Roenicke, Raik ;

Bartnik, Dirk ;

Brener, Oleksandr ;

Kutzsche, Janine ;

Horn, Anselm H. C. ;

Hellmert, Marco ;

Polkowska, Jolanta ;

Gottmann, Kurt ;

Reymann, Klaus G. ;

Funke, S. Aileen ;

Nagel-Steger, Luitgart ;

Moriscot, Christine ;

Schoehn, Guy ;

Sticht, Heinrich ;

Willbold, Dieter ;

Schrader, Thomas ;

Korth, Carsten .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (46) :8743-8746

[84] Modulation of aggregate size- and shape-distributions of the amyloid-β peptide by a designed β-sheet breaker [J].

Nagel-Steger, Luitgard ;

Demeler, Borries ;

Meyer-Zaika, Wolfgang ;

Hochdoerffer, Katrin ;

Schrader, Thomas ;

Willbold, Dieter .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2010, 39 (03) :415-422

[85] The role of high-density lipoprotein in inflammation [J].

Navab, M ;

Anantharamaiah, GM ;

Fogelman, AM .

TRENDS IN CARDIOVASCULAR MEDICINE, 2005, 15 (04) :158-161

[86] Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention [J].

Navab, Mohamad ;

Anantharamaiah, G. M. ;

Reddy, Srinivasa T. ;

Fogelman, Alan M. .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2006, 3 (10) :540-547

[87] Amyloid beta-peptide aggregation. What does it result in and how can it be prevented? [J].

Nerelius, Charlotte ;

Johansson, Jan ;

Sandegren, Anna .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 :1716-U3856

[88] Amyloid Imaging in Early Detection of Alzheimer's Disease [J].

Nordberg, Agneta .

NEURODEGENERATIVE DISEASES, 2010, 7 (1-3) :136-138

[89] Phage display affords peptides that modulate β-amyloid aggregation [J].

Orner, Brendan P. ;

Liu, Lin ;

Murphy, Regina M. ;

Kiessling, Laura L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (36) :11882-11889

[90] Recognition sequence design for peptidyl modulators of β-amyloid aggregation and toxicity [J].

Pallitto, MM ;

Ghanta, J ;

Heinzelman, P ;

Kiessling, LL ;

Murphy, RM .

BIOCHEMISTRY, 1999, 38 (12) :3570-3578

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