Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women

被引：73
作者：
Jeon, Young Joo [2 ,3 ]
Choi, Yi Seul [2 ,3 ]
Rah, HyungChul [2 ,3 ]
Kim, Su Yeoun [2 ,3 ]
Choi, Dong Hee [4 ]
Cha, Sun Hee [4 ]
Shin, Ji Eun [4 ]
Shim, Sung Han [1 ]
Lee, Woo Sik [1 ]
Kim, Nam Keun [2 ,3 ]
机构：
[1] CHA Univ, Fertil Ctr, CHA Gangnam Med Ctr, Seoul 135081, South Korea
[2] CHA Univ, CHA Bundang Med Ctr, Inst Clin Res, Songnam 463712, South Korea
[3] CHA Univ, Dept Biomed Sci, Coll Life Sci, Songnam 463712, South Korea
[4] CHA Univ, Dept Obstet & Gynecol, CHA Bundang Med Ctr, Songnam 463712, South Korea
来源：
GENE | 2012年 / 494卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
Genetic association; MicroRNA (miRNA); Recurrent spontaneous abortion (RSA); Polymorphism; GENE-GENE; EXPRESSION; CANCER; DIFFERENTIATION; PROLIFERATION; TRANSCRIPTION; RECOGNITION; METABOLISM; HOXB8; CELLS;
D O I：
10.1016/j.gene.2011.12.026
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA). Methods: We conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss. Results: RSA patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645-7.624). Conclusion: miR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：168 / 173
页数：6
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