Development of the Zebrafish Mesonephros

被引：34

作者：

Diep, Cuong Q. ^{[1
,2
,3
,4
]}

Peng, Zhenzhen ^{[5
]}

Ukah, Tobechukwu K. ^{[4
]}

Kelly, Paul M. ^{[4
]}

Daigle, Renee V. ^{[1
]}

Davidson, Alan J. ^{[1
,2
,3
,5
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Ctr Regenerat Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[3] Harvard Stem Cell Inst, Kidney Program, Cambridge, MA USA

[4] Indiana Univ Penn, Dept Biol, Indiana, PA 15705 USA

[5] Univ Auckland, Dept Mol Med & Pathol, Auckland 1142, New Zealand

来源：

GENESIS | 2015年 / 53卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

kidney; pronephros; nephron; EXPRESSION; GENES; IDENTIFICATION; SEGMENTATION; REGENERATION; PRONEPHROS; LIM1; WT1A;

D O I：

10.1002/dvg.22846

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney. genesis 53:257-269, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：257 / 269

页数：13

共 25 条

[1]

[Anonymous], 2007, GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRAF GUIDE LAB USE ZEBRA

[2] Identification and comparative expression analysis of a second wt1 gene in zebrafish [J].

Bollig, F ;

Mehringer, R ;

Perner, B ;

Hartung, C ;

Schäfer, M ;

Schartl, M ;

Volff, JN ;

Winkler, C ;

Englert, C .

DEVELOPMENTAL DYNAMICS, 2006, 235 (02) :554-561

[3] Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system [J].

Carroll, TJ ;

Park, JS ;

Hayashi, S ;

Majumdar, A ;

McMahon, AP .

DEVELOPMENTAL CELL, 2005, 9 (02) :283-292

[4] Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development [J].

Costantini, Frank ;

Kopan, Raphael .

DEVELOPMENTAL CELL, 2010, 18 (05) :698-712

[5] Zebrafish wnt9a is expressed in pharyngeal ectoderm and is required for palate and lower jaw development [J].

Curtin, Eugene ;

Hickey, Graham ;

Kamel, George ;

Davidson, Alan J. ;

Liao, Eric C. .

MECHANISMS OF DEVELOPMENT, 2011, 128 (1-2) :104-115

[6] Uncharted waters: nephrogenesis and renal regeneration in fish and mammals [J].

Davidson, Alan J. .

PEDIATRIC NEPHROLOGY, 2011, 26 (09) :1435-1443

[7] Transplantation of Cells Directly into the Kidney of Adult Zebrafish [J].

Diep, Cuong Q. ;

Davidson, Alan J. .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (51)

[8] Identification of adult nephron progenitors capable of kidney regeneration in zebrafish [J].

Diep, Cuong Q. ;

Ma, Dongdong ;

Deo, Rahul C. ;

Holm, Teresa M. ;

Naylor, Richard W. ;

Arora, Natasha ;

Wingert, Rebecca A. ;

Bollig, Frank ;

Djordjevic, Gordana ;

Lichman, Benjamin ;

Zhu, Hao ;

Ikenaga, Takanori ;

Ono, Fumihito ;

Englert, Christoph ;

Cowan, Chad A. ;

Hukriede, Neil A. ;

Handin, Robert I. ;

Davidson, Alan J. .

NATURE, 2011, 470 (7332) :95-U108

[9] The cellular basis of kidney development [J].

Dressler, Gregory R. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :509-529

[10] Kidney development and disease in the zebrafish [J].

Drummond, IA .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (02) :299-304

← 1 2 3 →