Icariin controlled release on a silk fibroin/mesoporous bioactive glass nanoparticles scaffold for promoting stem cell osteogenic differentiation

被引：17

作者：

Shen, Xiaofeng ^{[1
]}

Yu, Pengfei ^{[1
]}

Chen, Hua ^{[1
]}

Wang, Jiangping ^{[1
]}

Lu, Binjie ^{[1
]}

Cai, Xuefeng ^{[1
]}

Gu, Chun ^{[1
]}

Liang, Guoqiang ^{[1
]}

Hao, Donglin ^{[1
]}

Ma, Qihan ^{[1
]}

Li, Yuwei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Suzhou TCM Hosp, 889 West Wuzhong Rd, Suzhou, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 20期

关键词：

BONE MORPHOGENETIC PROTEIN-2; IN-VITRO; REGENERATION; PROLIFERATION; CHALLENGES; FIBROIN;

D O I：

10.1039/d0ra00637h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The treatment of bone defects caused by various reasons is still a major problem in orthopedic clinical work. Many studies on osteogenic implant materials have used various biologically active factors such as osteogenic inducers, but these biologically active factors have various side effects. Therefore, in this study, silk fibroin (SF) was used as a scaffold material, mesoporous bioactive glass nanoparticles (MBGNs) as a sustained release carrier, and the traditional Chinese drug icariin (ICA) was loaded to promote bone formation. The experiments in this study have proven that SF/MBGNs-ICA scaffolds can successfully load and release ICA for a long time, and the sustained-release ICA can promote the proliferation and differentiation of BMSCs for a long time. This controlled-release ICA organic/inorganic two-component scaffold material is expected to become a new bone grafting solution.

引用

页码：12105 / 12112

页数：8