Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis

被引：32

作者：

Bai, Suwen ^{[1
,2
]}

Wang, Zunyun ^{[2
]}

Wang, Minghua ^{[1
]}

Li, Junai ^{[1
]}

Wei, Yuan ^{[1
]}

Xu, Ruihuan ^{[1
]}

Du, Juan ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Affiliated Hosp 2, Longgang Dist Peoples Hosp, Shenzhen, Peoples R China

[2] Anhui Med Univ, Sch Basic Med Sci, Hefei, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

tumor-derived exosomes; metastasis; pre-metastatic niche; angiogenesis; immunosuppression; LYMPH-NODE METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; GASTROINTESTINAL STROMAL TUMOR; CERVICAL-CANCER PATIENTS; ACUTE MYELOID-LEUKEMIA; BRAIN METASTASIS; BREAST-CANCER; BONE METASTASIS; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.3389/fcell.2022.752818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor-derived exosomes (TDEs) are actively produced and released by tumor cells and carry messages from tumor cells to healthy cells or abnormal cells, and they participate in tumor metastasis. In this review, we explore the underlying mechanism of action of TDEs in tumor metastasis. TDEs transport tumor-derived proteins and non-coding RNA to tumor cells and promote migration. Transport to normal cells, such as vascular endothelial cells and immune cells, promotes angiogenesis, inhibits immune cell activation, and improves chances of tumor implantation. Thus, TDEs contribute to tumor metastasis. We summarize the function of TDEs and their components in tumor metastasis and illuminate shortcomings for advancing research on TDEs in tumor metastasis.

引用

页数：22

共 422 条

[21] Insulin-like growth factor-1 prevents miR-122 production in neighbouring cells to curtail its intercellular transfer to ensure proliferation of human hepatoma cells [J].

Basu, Sudarshana ;

Bhattacharyya, Suvendra N. .

NUCLEIC ACIDS RESEARCH, 2014, 42 (11) :7170-7185

[22] Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis [J].

Becker, Annette ;

Thakur, Basant Kumar ;

Weiss, Joshua Mitchell ;

Kim, Han Sang ;

Peinado, Hector ;

Lyden, David .

CANCER CELL, 2016, 30 (06) :836-848

[23] Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS [J].

Beckler, Michelle Demory ;

Higginbotham, James N. ;

Franklin, Jeffrey L. ;

Ham, Amy-Joan ;

Halvey, Patrick J. ;

Imasuen, Imade E. ;

Whitwell, Corbin ;

Li, Ming ;

Liebler, Daniel C. ;

Coffey, Robert J. .

MOLECULAR & CELLULAR PROTEOMICS, 2013, 12 (02) :343-355

[24] Translational models of prostate cancer bone metastasis [J].

Berish, Richard B. ;

Ali, Aymon N. ;

Telmer, Patrick G. ;

Ronald, John A. ;

Leong, Hon S. .

NATURE REVIEWS UROLOGY, 2018, 15 (07) :403-421

[25] microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer [J].

Bhagirath, Divya ;

Thao Ly Yang ;

Bucay, Nathan ;

Sekhon, Kirandeep ;

Majid, Shahana ;

Shahryari, Varahram ;

Dahiya, Rajvir ;

Tanaka, Yuichiro ;

Saini, Sharanjot .

CANCER RESEARCH, 2018, 78 (07) :1833-1844

[26] A retrospective study of incidence of bone metastasis in head and neck cancer [J].

Bhandari, Virendra ;

Jain, Ravi Kant .

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2013, 9 (01) :90-93

[27] uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells [J].

Biagioni, Alessio ;

Laurenzana, Anna ;

Menicacci, Beatrice ;

Peppicelli, Silvia ;

Andreucci, Elena ;

Bianchini, Francesca ;

Guasti, Daniele ;

Paoli, Paolo ;

Serrati, Simona ;

Mocali, Alessandra ;

Calorini, Lido ;

Del Rosso, Mario ;

Fibbi, Gabriella ;

Chilla, Anastasia ;

Margheri, Francesca .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2021, 78 (06) :3057-3072

[28] Transcriptomic Characterization, Chemosensitivity and Regulatory Effects of Exosomes in Spontaneous EMT/MET Transitions of Breast Cancer Cells [J].

Bigagli, Elisabetta ;

Cinci, Lorenzo ;

D'Ambrosio, Mario ;

Luceri, Cristina .

CANCER GENOMICS & PROTEOMICS, 2019, 16 (03) :163-173

[29] Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment [J].

Brabletz, T ;

Jung, A ;

Reu, S ;

Porzner, M ;

Hlubek, F ;

Kunz-Schughart, LA ;

Knuechel, R ;

Kirchner, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10356-10361

[30] INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].

BROOKS, PC ;

MONTGOMERY, AMP ;

ROSENFELD, M ;

REISFELD, RA ;

HU, TH ;

KLIER, G ;

CHERESH, DA .

CELL, 1994, 79 (07) :1157-1164

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