The Underestimated and Overlooked Burden of Diarrhea and Constipation in Cancer Patients

被引：18

作者：

Moschen, Alexander R. ^{[1
]}

Sammy, Yossi ^{[2
]}

Marjenberg, Zoe ^{[3
]}

Heptinstall, Amy B. ^{[3
]}

Pooley, Nick ^{[3
]}

Marczewska, Agnieszka M. ^{[2
]}

机构：

[1] Kepler Univ Hosp, Linz, Austria

[2] Nestle Hlth Sci, Vevey, Switzerland

[3] Maverex Ltd, Newcastle Upon Tyne, Tyne & Wear, England

来源：

CURRENT ONCOLOGY REPORTS | 2022年 / 24卷 / 07期

关键词：

Diarrhea; Constipation; Gastrointestinal dysfunction; Gut microbiome; Burden of disease; CHEMOTHERAPY-INDUCED DIARRHEA; COLORECTAL-CANCER; GUT MICROBIOME; CLINICAL-PRACTICE; ADVERSE EVENTS; MANAGEMENT; ILLNESS; SURVIVORS; INFORMATION; PREVENTION;

D O I：

10.1007/s11912-022-01267-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of Review This review aims to summarize and discuss the diverse causes of two major gastrointestinal dysfunction symptoms, diarrhea and constipation, in cancer patients. We also discuss short- and long-term clinical, economic, and humanistic consequences, including the impact on cancer treatment regimens and patient quality of life, highlighting the limitations of the literature. Recent Findings Diarrhea and constipation as a result of cancer and its treatment can risk the success of anti-cancer therapies by requiring treatment delay or withdrawal, and imposes a substantial humanistic burden in patients with cancer. Despite its importance and frequency, gastrointestinal side effects may be overlooked due to the focus on cancer treatment, and the impact on patients may be underestimated. Additionally, the burden reported may not fully reflect current cancer management, particularly the true impact of economic consequences. A full understanding of the burden of diarrhea and constipation in patients with cancer is required, including broad evaluation of clinical considerations, the patient experience, and an updated assessment of economic burden. This would improve caregivers' appreciation of the impact of gastrointestinal dysfunction and aid the prioritization of future research efforts.

引用

页码：861 / 874

页数：14

共 102 条

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