LiCl-mediated preparation of highly functionalized benzylic zinc chlorides

被引：145

作者：

Metzger, Albrecht ^{[1
]}

Schade, Matthias A. ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 06期

关键词：

D O I：

10.1021/ol7030697

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of zinc dust (1.5-2.0 equiv) and LiCl (1.5-2.0 equiv), various benzylic chlorides bearing functional groups (iodide, cyanide, ester, ketone) are smoothly converted at 25 degrees C to the corresponding zinc reagents without homo-coupling (<5%). The utility of these benzylic zinc reagents is demonstrated by a short synthesis of papaverine.

引用

页码：1107 / 1110

页数：4

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