The role of the Wnt signalling pathway in colorectal tumorigenesis

被引：122

作者：

Behrens, J ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, D-91054 Erlangen, Germany

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷

关键词：

Wnt signalling; beta-catenin; APC; colorectal tumorigenesis; tumour progression; tumour genetics;

D O I：

10.1042/BST0330672

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes. Mutations in the tumour suppressor APC (adenomatous polyposis coli) genes occur early in the development of CRC and lead to the stabilization of the Wnt pathway component beta-catenin and to the constitutive activation of Wnt signalling. Stabilizing mutations of beta-catenin can also lead to its accumulation, qualifying beta-catenin as a proto-oncogene. Here I will summarize the biochemical interactions occurring in Writ signalling and describe how alterations in Wnt pathway components lead to CRC.

引用

页码：672 / 675

页数：4

共 50 条

[1] Axin-mediated CKI phosphorylation of β-catenin at Ser 45:: a molecular switch for the Wnt pathway [J].

Amit, S ;

Hatzubai, A ;

Birman, Y ;

Andersen, JS ;

Ben-Shushan, E ;

Mann, M ;

Ben-Neriah, Y ;

Alkalay, I .

GENES & DEVELOPMENT, 2002, 16 (09) :1066-1076

[2] Wnt3A plays a major role in the segmentation clock controlling somitogenesis [J].

Aulehla, A ;

Wehrle, C ;

Brand-Saberi, B ;

Kemler, R ;

Gossler, A ;

Kanzler, B ;

Herrmann, BG .

DEVELOPMENTAL CELL, 2003, 4 (03) :395-406

[3] Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition [J].

Bachelder, RE ;

Yoon, SO ;

Franci, C ;

de Herreros, AG ;

Mercurio, AM .

JOURNAL OF CELL BIOLOGY, 2005, 168 (01) :29-33

[4] An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells [J].

Bafico, A ;

Liu, GZ ;

Goldin, L ;

Harris, V ;

Aaronson, SA .

CANCER CELL, 2004, 6 (05) :497-506

[5] The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation [J].

Barker, N ;

Hurlstone, A ;

Musisi, H ;

Miles, A ;

Bienz, M ;

Clevers, H .

EMBO JOURNAL, 2001, 20 (17) :4935-4943

[6] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells [J].

Batlle, E ;

Sancho, E ;

Franci, C ;

Domínguez, D ;

Monfar, M ;

Baulida, J ;

de Herreros, AG .

NATURE CELL BIOLOGY, 2000, 2 (02) :84-89

[7] Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[8] Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[9] Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment [J].

Brabletz, T ;

Jung, A ;

Reu, S ;

Porzner, M ;

Hlubek, F ;

Kunz-Schughart, LA ;

Knuechel, R ;

Kirchner, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10356-10361

[10] The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [J].

Cano, A ;

Pérez-Moreno, MA ;

Rodrigo, I ;

Locascio, A ;

Blanco, MJ ;

del Barrio, MG ;

Portillo, F ;

Nieto, MA .

NATURE CELL BIOLOGY, 2000, 2 (02) :76-83

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