Neuroendocrine tumor metastatic to the orbit treated with radiotherapy

Neuroendocrine tumors are rare neoplasms that only rarely metastasize to the orbit. Given that patients with these tumors may have prolonged survival despite dissemination, maintaining quality of life by providing early diagnosis and effective treatment to preserve vision and comfort is a fundamental issue. We report the case of a 79-year old woman who presented with well-differentiated metastatic neuroendocrine tumor to the liver with no carcinoid syndrome and was started on intramuscular long-acting octreotide with disease stabilization. Two years later she developed right-sided diplopia associated with mild eye discomfort, proptosis and reddening. An magnetic resonance imaging showed a 2.1 cm mass in the right orbit and further biopsy confirmed a neuroendocrine tumor metastases. The patient was treated with a four-week course of stereotactic radiotherapy to the right orbital metastases (4000 cGy in 20 fractions) with a minor conjunctivitis as the only side effect. Eighteen months later after it, she remains well and with no visual loss. (C) 2013 Baishideng. All rights reserved.