Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research

被引：89
作者：
Ceccarelli, Simona M. [1 ]
Chomienne, Odile [1 ]
Gubler, Marcel [1 ]
Arduini, Arduino [2 ]
机构：
[1] F Hoffmann La Roche Ltd, Div Pharmaceut, CH-4070 Basel, Switzerland
[2] CoreQuest Sagl, CH-6934 Bioggio, Switzerland
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 09期
关键词：
FATTY-ACID OXIDATION; PALMOXIRATE METHYL 2-TETRADECYLGLYCIDATE; PROLIFERATOR-ACTIVATED RECEPTOR; MALONYL-COA SENSITIVITY; ORAL HYPOGLYCEMIC AGENT; PALMITOYL TRANSFERASE-I; DECREASES FOOD-INTAKE; PERFUSED RAT HEARTS; N-TERMINAL DOMAIN; HEPATIC CARNITINE;
D O I：
10.1021/jm100809g
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：3109 / 3152
页数：44
相关论文
共 293 条
[1]   Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes [J].
AbdelAleem, S ;
ElMerzabani, MM ;
SayedAhmed, M ;
Taylor, DA ;
Lowe, JE .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (02) :789-797
[2]   Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets [J].
Abu-Elheiga, L ;
Oh, WK ;
Kordari, P ;
Wakil, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10207-10212
[3]  
Ackermann J., 2008, [No title captured], Patent No. [US20080103182, 20080103182]
[4]  
Ackermann J., 2007, [No title captured], Patent No. [US20070060567, 20070060567]
[5]  
Ackermann J., 2007, PCT Int. Appl., Patent No. [WO2007063012, 2007063012, WO2007063012 (A1)]
[6]  
Ackermann J., 2007, [No title captured], Patent No. [WO2007093507, 2007093507]
[7]   Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat [J].
Adams, SH ;
Esser, V ;
Brown, NF ;
Ing, NH ;
Johnson, L ;
Foster, DW ;
McGarry, JD .
BIOLOGY OF REPRODUCTION, 1998, 59 (06) :1399-1405
[8]   DIFFERENCES BETWEEN HUMAN, RAT AND GUINEA-PIG HEPATOCYTE CULTURES - A COMPARATIVE-STUDY OF THEIR RATES OF BETA-OXIDATION AND ESTERIFICATION OF PALMITATE AND THEIR SENSITIVITY TO R-ETOMOXIR [J].
AGIUS, L ;
PEAK, M ;
SHERRATT, HSA .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (09) :1711-1715
[9]   STEREOSPECIFICITY OF THE INHIBITION BY ETOMOXIR OF FATTY-ACID AND CHOLESTEROL-SYNTHESIS IN ISOLATED RAT HEPATOCYTES [J].
AGIUS, L ;
MEREDITH, EJ ;
SHERRATT, HSA .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (09) :1717-1720
[10]   EFFECTS OF 2[5(4-CHLORPHENYL)PENTYL]OXIRANE-2-CARBOXYLATE ON FATTY-ACID SYNTHESIS AND FATTY-ACID OXIDATION IN ISOLATED RAT HEPATOCYTES [J].
AGIUS, L ;
PILLAY, D ;
ALBERTI, KGMM ;
SHERRATT, HSA .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (15) :2651-2654
12345678910