Circulating tumor cells (CTCs) for the noninvasive monitoring and personalization of non-small cell lung cancer (NSCLC) therapies

被引：23

作者：

Pawlikowska, Patrycja ^{[1
,2
]}

Faugeroux, Vincent ^{[1
,2
]}

Oulhen, Marianne ^{[2
]}

Aberlenc, Agathe ^{[2
]}

Tayoun, Tala ^{[1
,2
]}

Pailler, Emma ^{[1
,2
,3
]}

Farace, Francoise ^{[1
,2
]}

机构：

[1] INSERM, Identificat Mol Predictors & New Targets Canc Tre, Villejuif, France

[2] Univ Paris Saclay, Gustave Roussy, Circulating Tumor Cells Translat Platform, Villejuif, France

[3] Harvard Med Sch, Broad Inst Harvard & MIT, Dana Farber Canc Inst, DFCI Longwood Ctr, Boston, MA USA

来源：

JOURNAL OF THORACIC DISEASE | 2019年 / 11卷

关键词：

Circulating tumor cells (CTC); non-small cell lung cancer (NSCLC); liquid biopsy; WHOLE-GENOME AMPLIFICATION; ACQUIRED-RESISTANCE; CHROMOSOMAL INSTABILITY; MOLECULAR ANALYSIS; OPEN-LABEL; PROGNOSTIC-SIGNIFICANCE; METASTATIC PROSTATE; TARGETED THERAPY; CLINICAL UTILITY; EGFR MUTATION;

D O I：

10.21037/jtd.2018.12.80

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Growing evidences for tumor heterogeneity confirm that single-tumor biopsies frequently fail to reveal the widespread mutagenic profile of tumor. Repeated biopsies are in most cases unfeasible, especially in advanced cancers. We describe here how circulating tumor cells (CTCs) isolated from minimally invasive blood sample might inform us about intratumor heterogeneity, tumor evolution and treatment resistance. We also discuss the advances of CTCs research, most notably in molecularly selected non-small cell lung cancer (NSCLC) patients, highlighting challenges and opportunities related to personalized therapy.

引用

页码：S45 / S56

页数：12

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