Mitochondria, free radicals, and neurodegeneration

被引：374

作者：

Beal, MF ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(96)80100-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A central role for defective mitochondrial energy production, and the resulting increased levels of free radicals, in the pathogenesis of various neurodegenerative diseases is gaining increasing acceptance. Defects in energy metabolism may contribute to both excitotoxicity and oxidative damage. Evidence implicating energy defects in neurodegenerative diseases comes from similarities to known mitochondrial disorders, including delayed and variable age of onset, slow progression, and symmetric degeneration of circumscribed groups of neurons.

引用

页码：661 / 666

页数：6

共 45 条

[1]

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