Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells

被引：21

作者：

Xi, Yue ^{[1
,2
]}

Gao, Hang ^{[1
]}

Callaghan, Michael U. ^{[2
]}

Fribley, Andrew M. ^{[2
,3
]}

Garshott, Danielle M. ^{[2
]}

Xu, Zhi-Xiang ^{[1
,4
]}

Zeng, Qinghua ^{[1
,4
]}

Li, Yu-Lin ^{[1
]}

机构：

[1] Jilin Univ, Norman Bethune Coll Med, Minist Educ, Key Lab Pathobiol, Changchun 130021, Peoples R China

[2] Wayne State Univ, Dept Otolaryngol, Carmen & Ann Adams Dept Pediat, Detroit, MI 48201 USA

[3] Karmanos Canc Inst, Mol Therapeut Program, Detroit, MI 48201 USA

[4] Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA

来源：

JOURNAL OF CANCER | 2015年 / 6卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Curcumin; Bik; caspase-9; caspase-3; apoptosis; squamous cell carcinoma; natural product; head and neck cancer; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; NF-KAPPA-B; CANCER STATISTICS; SIGNAL TRANSDUCER; APOPTOSIS; ACTIVATION; PATHWAYS; DEATH; PROLIFERATION;

D O I：

10.7150/jca.11185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Naturally occurring diarylheptanoid curcumin (CUR), a principal component of the Asian spice turmeric, has been shown to have anti-cancer effects in many tumor types. However, a detailed mechanism regarding CUR induced tumor cell killing remain to be comprehensively explored. Using two head neck squamous cell carcinoma (HNSCC) cell lines FaDu (hypopharyngeal) and Cal27 (tongue), we demonstrated a novel mechanism by which CUR levies the cytotoxic effect. We found that CUR induced upregulation of pro-apoptotic Bik, down-regulation of survival signaling by AKT and NF-kappa B prior to the induction of the caspase-cascade reduction of cell proliferation, are primary mechanisms of CUR-induced cell death, thus providing insights into the anti-tumor activity of CUR in HNSCC cells.

引用

页码：327 / 332

页数：6

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[1] Intracellular signal transduction pathway proteins as targets for cancer therapy [J].