A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury

被引：21

作者：

Bi, Wei ^{[3
]}

Bi, Yue ^{[4
]}

Xue, Ping ^{[3
]}

Zhang, Yanrong ^{[3
]}

Gao, Xiang ^{[3
]}

Wang, Zhibo ^{[3
]}

Li, Meng ^{[3
]}

Baudy-Floc'h, Michele ^{[5
]}

Ngerebara, Nathaniel ^{[1
]}

Gibson, K. Michael ^{[2
]}

Bi, Lanrong ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[2] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA

[3] HeBei Med Univ, Dept Surg, Hosp 2, Shijiazhuang 050000, Peoples R China

[4] HeBei Med Univ, Sch Basic Med Sci, Shijiazhuang 050000, Peoples R China

[5] Univ Rennes 1, UMR CNRS ICMV 6226, F-35042 Rennes, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 05期

关键词：

Ischemia-reperfusion injury; beta-Carboline alkaloid-peptide conjugates; Antioxidant; Thrombolytic activity; DUAL-ACTING AGENTS; RADICAL SCAVENGERS; ISCHEMIA; CONSEQUENCES; PERMEABILITY; ANTIOXIDANTS; DERIVATIVES; TOURNIQUET; MANAGEMENT; DESIGN;

D O I：

10.1016/j.ejmech.2011.01.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe a novel class of beta-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that beta-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat. Published by Elsevier Masson SAS.

引用

页码：1453 / 1462

页数：10

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