A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury

被引：21
作者：
Bi, Wei [3 ]
Bi, Yue [4 ]
Xue, Ping [3 ]
Zhang, Yanrong [3 ]
Gao, Xiang [3 ]
Wang, Zhibo [3 ]
Li, Meng [3 ]
Baudy-Floc'h, Michele [5 ]
Ngerebara, Nathaniel [1 ]
Gibson, K. Michael [2 ]
Bi, Lanrong [1 ]
机构：
[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA
[2] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA
[3] HeBei Med Univ, Dept Surg, Hosp 2, Shijiazhuang 050000, Peoples R China
[4] HeBei Med Univ, Sch Basic Med Sci, Shijiazhuang 050000, Peoples R China
[5] Univ Rennes 1, UMR CNRS ICMV 6226, F-35042 Rennes, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 05期
关键词：
Ischemia-reperfusion injury; beta-Carboline alkaloid-peptide conjugates; Antioxidant; Thrombolytic activity; DUAL-ACTING AGENTS; RADICAL SCAVENGERS; ISCHEMIA; CONSEQUENCES; PERMEABILITY; ANTIOXIDANTS; DERIVATIVES; TOURNIQUET; MANAGEMENT; DESIGN;
D O I：
10.1016/j.ejmech.2011.01.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We describe a novel class of beta-carboline alkaloid-peptide conjugates that possess both free radical scavenging and thrombolytic activity. These conjugates demonstrate therapeutic efficacy in a rat arterial thrombosis assay, as well as free radical scavenging capacity as evaluated in a PC12 cell survival assay. Our results indicate that beta-carboline alkaloid-peptide conjugate 26a exerts a significant protective effect against local and remote organ injury induced by limb I/R injury in the rat. Published by Elsevier Masson SAS.
引用
收藏
页码：1453 / 1462
页数：10
相关论文
共 32 条
[1]   L-Alanyl-Glutamine Preoperative Infusion in Patients with Critical Limb Ischemia Subjected to Distal Revascularization Reduces Tissue Damage and Protects from Oxidative Stress [J].
Alves, Wellington Forte ;
Aguiar, Erika Elisa ;
Guimaraes, Sergio Botelho ;
da Silva Filho, Antonio Ribeiro ;
Antero Pinheiro, Petrucia Maria ;
Dias Soares, Gabriel dos Santos ;
de Vasconcelos, Paulo Roberto Leitao .
ANNALS OF VASCULAR SURGERY, 2010, 24 (04) :461-467
[2]   ISOLATION OF VASOACTIVE PEPTIDES FROM HUMAN FIBRIN AND FIBRINOGEN DEGRADED BY PLASMIN [J].
BELEW, M ;
GERDIN, B ;
PORATH, J ;
SALDEEN, T .
THROMBOSIS RESEARCH, 1978, 13 (06) :983-994
[3]  
Beuge J.A., 1978, METHOD ENZYMOL, V52, P302
[4]  
Beutler E., 1975, Red Cell Metabolism. A manual of biochemical methods, V2nd
[5]   Design, synthesis and cardioprotective effect of a new class of dual-acting agents:: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates [J].
Bi, Wei ;
Cai, Jianhui ;
Liu, Sanguang ;
Baudy-Floc'h, Michele ;
Bi, Lanrong .
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (22) :6909-6919
[6]   Dual-acting agents that possess free radical scavenging and antithrombotic activities:: Design, synthesis, and evaluation of phenolic tetrahydro-β-carboline RGD peptide conjugates [J].
Bi, Wei ;
Bi, Lanrong ;
Cai, Jianhui ;
Liu, Sanguang ;
Peng, Shiqi ;
Fischer, Nicholas O. ;
Tok, Jeffrey B. -H. ;
Wang, Guohua .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (17) :4523-4527
[7]   Synthesis and Characterization of Novel Indole Derivatives Reveal Improved Therapeutic Agents for Treatment of Ischemia/Reperfusion (I/R) Injury [J].
Bi, Wei ;
Bi, Yue ;
Xue, Ping ;
Zhang, Yanrong ;
Gao, Xiang ;
Wang, Zhibo ;
Li, Meng ;
Baudy-Floc'h, Michele ;
Ngerebara, Nathaniel ;
Gibson, K. Michael ;
Bi, Lanrong .
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (18) :6763-6767
[8]   Metabolic Consequences of Acute Limb Ischemia and Their Clinical Implications [J].
Eliason, Jonathan L. ;
Wakefield, Thomas W. .
SEMINARS IN VASCULAR SURGERY, 2009, 22 (01) :29-33
[9]   EFFECT OF FIBRIN DEGRADATION PRODUCTS ON MICRO-VASCULAR PERMEABILITY [J].
GERDIN, B ;
SALDEEN, T .
THROMBOSIS RESEARCH, 1978, 13 (06) :995-1006
[10]   Tetrahydro-β-carboline alkaloids occur in fruits and fruit juices.: Activity as antioxidants and radical scavengers [J].
Herraiz, T ;
Galisteo, J .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (24) :7156-7161
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