Regulation of nicotinic acetylcholine receptors in Alzheimer's disease: A possible role of chaperones

被引：21
作者：
Sadigh-Eteghad, Saeed [1 ]
Majdi, Alireza [1 ]
Talebi, Mahnaz [1 ]
Mahmoudi, Javad [1 ]
Babri, Shirin [1 ]
机构：
[1] Tabriz Univ Med Sci, Neurosci Res Ctr NSRC, Tabriz, Iran
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2015年 / 755卷
关键词：
Regulation; Nicotinic acetylcholine receptors; Alzheimer; Chaperone; AMYLOID-INDUCED APOPTOSIS; VISININ-LIKE PROTEIN-1; CA2+ SENSOR VILIP-1; PHARMACOLOGICAL CHAPERONES; NEUROFIBRILLARY TANGLES; UP-REGULATION; FUNCTIONAL EXPRESSION; AGONIST SENSITIVITY; SURFACE EXPRESSION; COGNITIVE DECLINE;
D O I：
10.1016/j.ejphar.2015.02.047
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nicotinic acetylcholine receptors (nAChRs) seem to play an integral role in the progress and/or prevention of Alzheimer's diseases (AD). Functional abnormalities and problems in biogenesis and trafficking of nAChRs are two major culprits in AD; on the other hand, chaperones modulate post-translational changes in nAChRs. Moreover, they indirectly regulate nAChRs by controlling AD-related proteins such as tau and amyloid beta (A beta). In this review, we go through recent studies which are showing that chaperones modulate the expression of nAChRs in a subtype-specific manner and explain how AD progress is affected by nAChRs chaperoning. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：34 / 41
页数：8
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