In vitro degradability and bioactivity of oxidized bacterial cellulose-hydroxyapatite composites

被引：56

作者：

Chagas Gomes Luz, Erika Patricia ^{[1
]}

Silva Chaves, Paulo Hiago ^{[2
]}

Pinto Vieira, Lidia de Araujo ^{[2
]}

Ribeiro, Sadwa Fernandes ^{[2
]}

Borges, Maria de Fatima ^{[2
]}

Andrade, Fabia Karine ^{[1
,2
]}

Muniz, Celli Rodrigues ^{[2
]}

Infantes-Molina, Antonia ^{[3
]}

Rodriguez-Castellon, Enrique ^{[3
]}

Rosa, Morsyleide de Freitas ^{[2
]}

Vieira, Rodrigo Silveira ^{[1
]}

机构：

[1] Fed Univ Ceara UFC, Dept Chem Engn, Bloco 709, BR-60455760 Fortaleza, Ceara, Brazil

[2] Embrapa Agroind Trop CNPAT, Rua Dra Sara Mesquita 2270, BR-60511110 Fortaleza, Ceara, Brazil

[3] Univ Malaga, Fac Sci, Dept Inorgan Chem Crystallog & Mineral, Campus Teatinos S-N, E-29071 Malaga, Spain

来源：

CARBOHYDRATE POLYMERS | 2020年 / 237卷 / 237期

关键词：

Oxidized bacterial cellulose; Hydroxyapatite; Hybrids composites; Bone tissue; OXIDATION; STATE; SCAFFOLD;

D O I：

10.1016/j.carbpol.2020.116174

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hydroxyapatite-associated bacterial cellulose (BC/HA) is a promising composite for biomedical applications. However, this hybrid composite has some limitations due to its low in vivo degradability. The objective of this work was to oxidize BC and BC/HA composites for different time periods to produce 2,3 dialdehyde cellulose (DAC). The BC and oxidized BC (OxBC) membranes were mineralized to obtain the hybrid materials (BC/HA and OxBC/HA) and their physico-chemical, degradability, and bioactivity properties were studied. The results showed that OxBC/HA was more bioactive and degradable than BC/HA, which isa function of the degree of BC oxidation. High glucose levels in the BC degradation were observed as a function of oxidation degree, and other products, such as butyric acid and acetic acid resulted from DAC degradation. Therefore, this chemical modification reaction favors BC degradation, making it a good biodegradable and bioactive material with a potential for bone regeneration applications.

引用

页数：10

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