Enantioselective pinacol coupling of aldehydes mediated and catalyzed by chiral titanium complexes

被引：85

作者：

Bensari, A

Renaud, JL

Riant, O

机构：

[1] Catholic Univ Louvain, Lab Chim Organ & Med, Dept Chim, B-1348 Louvain, Belgium

[2] Univ Paris 11, Inst Chim Mol Orsay, Lab Catalyse Mol, F-91405 Orsay, France

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 24期

关键词：

D O I：

10.1021/ol016664a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Starting from easily available chiral Schiff bases, a straightforward synthesis of air-stable titanium(IV) complexes was devised. Asymmetric pinacol coupling of aromatic aldehydes mediated and catalyzed by the corresponding low valent complexes afforded the chiral diols with high yields and enantioselectivities up to 91%.

引用

页码：3863 / 3865

页数：3

共 31 条

[1] Highly diastereoselective pinacol coupling of aldehydes catalyzed by titanium Schiff base complexes [J].