共 42 条
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis
被引:166
作者:

Saurin, Adrian T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands

van der Waal, Maike S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Med Oncol, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands

Medema, Rene H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Med Oncol, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands

Lens, Susanne M. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Med Oncol, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands

Kops, Geert J. P. L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands
机构:
[1] Univ Med Ctr Utrecht, Mol Canc Res & Canc Genom Ctr, NL-3584 CG Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dept Med Oncol, NL-3584 CG Utrecht, Netherlands
来源:
NATURE COMMUNICATIONS
|
2011年
/
2卷
基金:
欧洲研究理事会;
关键词:
ANAPHASE-PROMOTING COMPLEX/CYCLOSOME;
KINETOCHORE-MICROTUBULE ATTACHMENT;
CHROMOSOMAL PASSENGER COMPLEX;
SPINDLE-ASSEMBLY CHECKPOINT;
MITOTIC CHECKPOINT;
CENP-E;
KINASE;
MAD2;
DYNAMICS;
BUBR1;
D O I:
10.1038/ncomms1319
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The mitotic checkpoint prevents mitotic exit until all chromosomes are attached to spindle microtubules. Aurora B kinase indirectly invokes this checkpoint by destabilizing incorrect attachments; however, a more direct role remains controversial. In contrast, activity of the kinase Mps1 is indispensible for the mitotic checkpoint. Here we show that Aurora B and Hec1 are needed for efficient Mps1 recruitment to unattached kinetochores, allowing rapid Mps1 activation at the onset of mitosis. Live monitoring of cyclin B degradation reveals that this is essential to establish the mitotic checkpoint quickly at the start of mitosis. Delayed Mps1 activation and checkpoint establishment upon Aurora B inhibition or Hec1 depletion are rescued by tethering Mps1 to kinetochores, demonstrating that Mps1 recruitment is the primary role of Aurora B and Hec1 in mitotic checkpoint signalling. These data demonstrate a direct role for Aurora B in initiating the mitotic checkpoint rapidly at the onset of mitosis.
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页数:9
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