Viscous Topical Is More Effective Than Nebulized Steroid Therapy for Patients With Eosinophilic Esophagitis

被引：234

作者：

Dellon, Evan S. ^{[1
,2
]}

Sheikh, Arif ^{[3
]}

Speck, Olga ^{[4
]}

Woodward, Kimberly ^{[4
]}

Whitlow, Ann B. ^{[3
]}

Hores, Jessica M. ^{[1
]}

Ivanovic, Marija ^{[3
]}

Chau, Allen ^{[3
]}

Woosley, John T. ^{[4
]}

Madanick, Ryan D. ^{[1
,2
]}

Orlando, Roy C. ^{[1
,2
]}

Shaheen, Nicholas J. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, Ctr Esophageal Dis & Swallowing, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Ctr Gastrointestinal Biol & Dis, Div Gastroenterol & Hepatol,Dept Med, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Dept Radiol, Div Nucl Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Sch Med, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

来源：

GASTROENTEROLOGY | 2012年 / 143卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Clinical Trial; Corticosteroid; Esophagus; Inflammation; PLACEBO-CONTROLLED TRIAL; SWALLOWED FLUTICASONE; HISTOPATHOLOGIC VARIABILITY; CONSENSUS RECOMMENDATIONS; BUDESONIDE SUSPENSION; DOUBLE-BLIND; CHILDREN; ADULTS; VALIDATION; DYSPHAGIA;

D O I：

10.1053/j.gastro.2012.04.049

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We performed a randomized trial to compare nebulized and viscous topical corticosteroid treatments for eosinophilic esophagitis (EoE). Subjects with incident EoE (n = 25) received budesonide 1 mg twice daily, either nebulized and then swallowed (NEB) or as an oral viscous slurry (OVB), for 8 weeks. Baseline eosinophil counts for the NEB and OVB groups were 101 and 83 (P = .62). Posttreatment counts were 89 and 11 (P = .02). The mucosal medication contact time, measured by scintigraphy, was higher for the OVB group than the NEB group (P < .005) and was inversely correlated with eosinophil count (R = -0.67; P = .001). OVB was more effective than NEB in reducing numbers of esophageal eosinophils in patients with EoE. OVB provided a significantly higher level of esophageal exposure to the therapeutic agent, which correlated with lower eosinophil counts.

引用

页码：321 / +

页数：5

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