The hydroxylation at C-17 in the biosynthesis of the diterpenoid aphidicolin

被引：6

作者：

Hanson, JR

Hitchcock, PB

Jarvis, AG

机构：

[1] School of Molecular Sciences, University of Sussex, Brighton

来源：

PHYTOCHEMISTRY | 1997年 / 44卷 / 06期

关键词：

Cephalosporium aphidicola; biosynthesis; diterpenoid; aphidicolin; C-17; hydroxylation;

D O I：

10.1016/S0031-9422(96)00713-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hydroxylation at C-17 in aphidicolin biosynthesis is inhibited by a 17-thiol. A metabolite hydroxylated at C-17 and retaining the cyclopropane ring was obtained from 3 alpha,18-dihydroxy-15 beta,16 beta-methanoaphidicolane whilst aphidicolin itself was obtained from 3 alpha,18-dihydroxyaphidicolane when these substrates were incubated with the fungus, Cephalosporium aphidicola. Copyright (C) 1997 Elsevier Science Ltd.

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收藏

页码：1055 / 1059

页数：5

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