Synthesis, Neurotoxicity and Anticonvulsant Study of Some Benzothiazole Analogs

被引：0

作者：

Sethi, Kalyan K. ^{[1
]}

Verma, Saurabh M. ^{[2
]}

Prasanthi, Naru ^{[2
]}

Annapurna, Mathrusri M. ^{[1
]}

机构：

[1] GITAM Univ, GITAM Inst Pharm, Visakhapatnam 530045, Andhra Pradesh, India

[2] Birla Inst Technol, Dept Pharmaceut Sci, Mesra Ranchi 835215, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 08期

关键词：

Benzothiazole sulfonamides; Carbonic Anhydrase Inhibitors; Neurotoxicity; Anticonvulsant; CARBONIC-ANHYDRASE INHIBITORS; DERIVATIVES; TARGETS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzothiazole sulfonamides, thiosemicarbazones and guanidine derivatives were synthesized by different pathways and tested for the neurotoxicity studies by the Rotarod method. The minimal motor impairment, the significant results were found with compounds (7) and (3). Some of these compounds also showed anticonvulsant activity by decreasing the duration of convulsions in albino mice. Compound (3), (7) and also compound (2) were found to be increased in the onset of convulsion and other test drugs showed moderate protection and animals were recovered in these groups.

引用

页码：774 / 777

页数：4

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