COVID-19 and hyperammonemia: Potential interplay between liver and brain dysfunctions

被引：10

作者：

Bobermin, Larissa Daniele ^{[1
]}

Quincozes-Santos, Andre ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande Do Sul, Inst Ciencias Bas Saude, Programa Posgrad Ciencias Biol Bioquim, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande Do Sul, Inst Ciencias Bas Saude, Dept Bioquim, Rua Ramiro Barcelos 2600, BR-90035 Porto Alegre, RS, Brazil

来源：

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH | 2021年 / 14卷

关键词：

COVID-19; Liver dysfunction; Brain dysfunction; Ammonia; Astrocytes; SYSTEMIC INFLAMMATION;

D O I：

10.1016/j.bbih.2021.100257

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although COVID-19 affects the respiratory system, extrapulmonary manifestations frequently occur, including encephalopathy and liver damage. Here, we want to call attention to a possible connection between liver and brain dysfunctions, in which ammonia can play a role targeting astrocytes. Importantly, astrocyte dysfunction can produce future and/or long-term neurological consequences.

引用

页数：3

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