Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi

被引：37

作者：

He, Wen-Jun ^{[1
,2
]}

Chu, Hong-Biao ^{[1
]}

Zhang, Yu-Mei ^{[1
]}

Han, Hong-Jin ^{[1
]}

Yan, He ^{[1
,2
]}

Zeng, Guang-Zhi ^{[1
]}

Fu, Zhao-Hui ^{[1
]}

Olubanke, Ogunlana ^{[3
]}

Tan, Ning-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

[3] Covenant Univ, Dept Biol Sci, Coll Sci & Technol, Ota, Ogun State, Nigeria

来源：

PLANTA MEDICA | 2011年 / 77卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Pseudolarix kaempferi; Pinaceae; lignans; terpenoids; antimicrobial; cytotoxic; TU-JIN-PI; ACID-B; SEQUOIA-SEMPERVIRENS; DITERPENOIDS; IDENTIFICATION; TRITERPENOIDS; CONSTITUENTS; GLYCOSIDES;

D O I：

10.1055/s-0031-1280020

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new compounds, including four lignans, (+)-(8S, 8'S)-9,9'-dibenzoylsecoisolariciresinol (1), (+)-(8S*, 8'R*)-4,4'-dimethyloxomatairesinol (2), (+)-(7S*, 8R*, 8'R*, 9'S*)-9'-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8-32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.

引用

页码：1924 / 1931

页数：8

共 31 条

[1]

[Anonymous], 2010, PHARMACOPOEIA CHIN 1, P16

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