Airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction

被引：14

作者：

Gebski, Eric B. ^{[1
]}

Anaspure, Omkar ^{[1
]}

Panettieri, Reynold A. ^{[1
]}

Koziol-White, Cynthia J. ^{[1
]}

机构：

[1] Rutgers State Univ, Rutgers Inst Translat Med & Sci, 89 French St,Room 4268, New Brunswick, NJ 08901 USA

来源：

MINERVA MEDICA | 2022年 / 113卷 / 01期

关键词：

Asthma; Bronchoconstriction; Bronchodilator agents; OPERATED CA2+ ENTRY; TNF-ALPHA; INTRACELLULAR CA2+; RYANODINE RECEPTOR; CD38; EXPRESSION; CONTRACTION; PROTEIN; CELLS; INTERLEUKIN-13; PHOSPHORYLATION;

D O I：

10.23736/S0026-4806.21.07283-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (AHR) associated with asthma. Emerging studies examining the phenotype of ASM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the AHR associated with the disease.

引用

页码：4 / 16

页数：13

共 104 条

[1] Regulation of Myosin Light-Chain Phosphatase Activity to Generate Airway Smooth Muscle Hypercontractility [J].

Alvarez-Santos, Mayra D. ;

Alvarez-Gonzalez, Marisol ;

Estrada-Soto, Samuel ;

Bazan-Perkins, Blanca .

FRONTIERS IN PHYSIOLOGY, 2020, 11

[2] Smooth-muscle myosin light-chain kinase content is increased in human sensitized airways [J].

Ammit, AJ ;

Armour, CL ;

Black, JL .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (01) :257-263

[3] Modulation of calcium homeostasis as a mechanism for altering smooth muscle responsiveness in asthma [J].

Amrani, Yassine ;

Panettieri, Reynold A., Jr. .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 2 (01) :39-45

[4]

Amrani Yassine, 1997, American Journal of Physiology, V273, pL1020

[5] Airway smooth muscle dynamics:: a common pathway of airway obstruction in asthma [J].

An, S. S. ;

Bai, T. R. ;

Bates, J. H. T. ;

Black, J. L. ;

Brown, R. H. ;

Brusasco, V. ;

Chitano, P. ;

Deng, L. ;

Dowell, M. ;

Eidelman, D. H. ;

Fabry, B. ;

Fairbank, N. J. ;

Ford, L. E. ;

Fredberg, J. J. ;

Gerthoffer, W. T. ;

Gilbert, S. H. ;

Gosens, R. ;

Gunst, S. J. ;

Halayko, A. J. ;

Ingram, R. H. ;

Irvin, C. G. ;

James, A. L. ;

Janssen, L. J. ;

King, G. G. ;

Knight, D. A. ;

Lauzon, A. M. ;

Lakser, O. J. ;

Ludwig, M. S. ;

Lutchen, K. R. ;

Maksym, G. N. ;

Martin, J. G. ;

Mauad, T. ;

McParland, B. E. ;

Mijailovich, S. M. ;

Mitchell, H. W. ;

Mitchell, R. W. ;

Mitzner, W. ;

Murphy, T. M. ;

Pare, P. D. ;

Pellegrino, R. ;

Sanderson, M. J. ;

Schellenberg, R. R. ;

Seow, C. Y. ;

Silveira, P. S. P. ;

Smith, P. G. ;

Solway, J. ;

Stephens, N. L. ;

Sterk, P. J. ;

Stewart, A. G. ;

Tang, D. D. .

EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (05) :834-860

[6] An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma [J].

An, Steven S. ;

Mitzner, Wayne ;

Tang, Wan-Yee ;

Ahn, Kwangmi ;

Yoon, A-Rum ;

Huang, Jessie ;

Kilic, Onur ;

Yong, Hwan Mee ;

Fahey, Jed W. ;

Kumar, Sarvesh ;

Biswal, Shyam ;

Holgate, Stephen T. ;

Panettieri, Reynold A., Jr. ;

Solway, Julian ;

Liggett, Stephen B. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (01) :294-297

[7] Cell stiffness, contractile stress and the role of extracellular matrix [J].

An, Steven S. ;

Kim, Jina ;

Ahn, Kwangmi ;

Trepat, Xavier ;

Drake, Kenneth J. ;

Kumar, Sarvesh ;

Ling, Guoyu ;

Purington, Carolyn ;

Rangasamy, Tirumalai ;

Kensler, Thomas W. ;

Mitzner, Wayne ;

Fredberg, Jeffrey J. ;

Biswal, Shyam .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 382 (04) :697-703

[8] Mechanisms of BDNF regulation in asthmatic airway smooth muscle [J].

Aravamudan, Bharathi ;

Thompson, Michael A. ;

Pabelick, Christina M. ;

Prakash, Y. S. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 311 (02) :L270-L279

[9] Cyclic nucleotide regulation of store-operated Ca2+ influx in airway smooth muscle [J].

Ay, B ;

Iyanoye, A ;

Sieck, GC ;

Prakash, YS ;

Pabelick, CM .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (02) :L278-L283

[10]

Ba M, 2009, CELL HEALTH CYTOSKEL, V1, P27

← 1 2 3 4 5 6 7 8 9 10 →