BeadArray™-based solutions for enabling the promise of pharmacogenomics

被引:20
作者
Fan, JB
Hu, SX
Craumer, WC
Barker, DL
机构
[1] Illumina Inc, San Diego, CA 92121 USA
[2] IMS Management Consulting, Plymouth Meeting, PA USA
关键词
D O I
10.2144/000112047
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A "one-size-fits-all" approach continues to characterize today's healthcare paradigm. But emergent rules, information, genomics tools, and economics are driving a fundamental and inevitable shift to a more personalized world of medicine. In this new world, the interests of insurers, regulators, suppliers, healthcare providers, and most important, patients, will have converged. The new goal will be the right treatment for the right individual at the right time. In this world, personalized medicine, through pharmacogenomics (PGx), will be the new healthcare paradigm. We will briefly examine healthcare trends and current opportunities for PGx development. We will then demonstrate how microarray technologies-among them bead-based approaches-have emerged as a key enabler for bringing home the promise of PGx.
引用
收藏
页码:583 / 588
页数:6
相关论文
共 56 条
[11]   Measurement of gene expression in archival paraffin-embedded tissues - Development and performance of a 92-gene reverse transcriptase-polymerase chain reaction assay [J].
Cronin, M ;
Pho, M ;
Dutta, D ;
Stephans, JC ;
Shak, S ;
Kiefer, MC ;
Esteban, JM ;
Baker, JB .
AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (01) :35-42
[12]   Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers - A new approach for the molecular analysis of paraffin-embedded cancer tissue [J].
Daigo, Y ;
Chin, SF ;
Gorringe, KL ;
Bobrow, LG ;
Ponder, BAJ ;
Pharoah, PDP ;
Caldas, C .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (05) :1623-1631
[13]   Delineation of prognostic biomarkers in prostate cancer [J].
Dhanasekaran, SM ;
Barrette, TR ;
Ghosh, D ;
Shah, R ;
Varambally, S ;
Kurachi, K ;
Pienta, KJ ;
Rubin, MA ;
Chinnaiyan, AM .
NATURE, 2001, 412 (6849) :822-826
[14]   Epigenetics in human disease and prospects for epigenetic therapy [J].
Egger, G ;
Liang, GN ;
Aparicio, A ;
Jones, PA .
NATURE, 2004, 429 (6990) :457-463
[15]  
Esteller M, 1999, CANCER RES, V59, P67
[16]   CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future [J].
Esteller, M .
ONCOGENE, 2002, 21 (35) :5427-5440
[17]   Drug therapy - Pharmacogenomics - Drug disposition, drug targets, and side effects [J].
Evans, WE ;
McLeod, HL .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (06) :538-549
[18]   Highly parallel SNP genotyping [J].
Fan, JB ;
Oliphant, A ;
Shen, R ;
Kermani, BG ;
Garcia, F ;
Gunderson, KL ;
Hansen, M ;
Steemers, F ;
Butler, SL ;
Deloukas, P ;
Galver, L ;
Hunt, S ;
McBride, C ;
Bibikova, M ;
Rubano, T ;
Chen, J ;
Wickham, E ;
Doucet, D ;
Chang, W ;
Campbell, D ;
Zhang, B ;
Kruglyak, S ;
Bentley, D ;
Haas, J ;
Rigault, P ;
Zhou, L ;
Stuelpnagel, J ;
Chee, MS .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2003, 68 :69-78
[19]   A versatile assay for high-throughput gene expression profiling on universal array matrices [J].
Fan, JB ;
Yeakley, JM ;
Bibikova, M ;
Chudin, E ;
Wickham, E ;
Chen, J ;
Doucet, D ;
Rigault, P ;
Zhang, BH ;
Shen, R ;
McBride, C ;
Li, HR ;
Fu, XD ;
Oliphant, A ;
Barker, DL ;
Chee, MS .
GENOME RESEARCH, 2004, 14 (05) :878-885
[20]   Timeline - The history of cancer epigenetics [J].
Feinberg, AP ;
Tycko, B .
NATURE REVIEWS CANCER, 2004, 4 (02) :143-153