BeadArray™-based solutions for enabling the promise of pharmacogenomics

被引:20
作者
Fan, JB
Hu, SX
Craumer, WC
Barker, DL
机构
[1] Illumina Inc, San Diego, CA 92121 USA
[2] IMS Management Consulting, Plymouth Meeting, PA USA
关键词
D O I
10.2144/000112047
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A "one-size-fits-all" approach continues to characterize today's healthcare paradigm. But emergent rules, information, genomics tools, and economics are driving a fundamental and inevitable shift to a more personalized world of medicine. In this new world, the interests of insurers, regulators, suppliers, healthcare providers, and most important, patients, will have converged. The new goal will be the right treatment for the right individual at the right time. In this world, personalized medicine, through pharmacogenomics (PGx), will be the new healthcare paradigm. We will briefly examine healthcare trends and current opportunities for PGx development. We will then demonstrate how microarray technologies-among them bead-based approaches-have emerged as a key enabler for bringing home the promise of PGx.
引用
收藏
页码:583 / 588
页数:6
相关论文
共 56 条
[1]   Towards quantitative mRNA analysis in paraffin-embedded tissues using real-time reverse transcriptase-polymerase chain reaction - A methodological study on lymph nodes from melanoma patients [J].
Abrahamsen, HN ;
Steiniche, T ;
Nexo, E ;
Hamilton-Dutoit, SJ ;
Sorensen, BS .
JOURNAL OF MOLECULAR DIAGNOSTICS, 2003, 5 (01) :34-41
[2]   Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma [J].
Alaminos, M ;
Davalos, V ;
Cheung, NKV ;
Gerald, WL ;
Esteller, M .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (16) :1208-1219
[3]   The genetics and genomics of cancer [J].
Balmain, A ;
Gray, J ;
Ponder, B .
NATURE GENETICS, 2003, 33 (Suppl 3) :238-244
[4]   Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel [J].
Barker, DL ;
Hansen, MST ;
Faruqi, AF ;
Giannola, D ;
Irsula, OR ;
Lasken, RS ;
Latterich, M ;
Makarov, V ;
Oliphant, A ;
Pinter, JH ;
Shen, R ;
Sleptsova, I ;
Ziehler, W ;
Lai, E .
GENOME RESEARCH, 2004, 14 (05) :901-907
[5]   Self-assembled random arrays: High-performance imaging and genomics applications on a high-density microarray platform [J].
Barker, DL ;
Theriault, G ;
Che, DP ;
Dickinson, T ;
Shen, R ;
Kain, R .
MICROARRAYS AND COMBINATORIAL TECHNOLOGIES FOR BIOMEDICAL APPLICATIONS: DESIGN, FABRICATION, AND ANALYSIS, 2003, 4966 :1-11
[6]   DNA hypermethylation in tumorigenesis - epigenetics joins genetics [J].
Baylin, SB ;
Herman, JG .
TRENDS IN GENETICS, 2000, 16 (04) :168-174
[7]   Gene expression profiles in formalin-fixed, paraffin-embedded tissues obtained with a novel assay for microarray analysis [J].
Bibikova, M ;
Yeakley, JM ;
Chudin, E ;
Jing, C ;
Wickham, E ;
Wang-Rodriguez, J ;
Fan, JB .
CLINICAL CHEMISTRY, 2004, 50 (12) :2384-2386
[8]   Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays [J].
Bibikova, M ;
Talantov, D ;
Chudin, E ;
Yeakley, JM ;
Chen, J ;
Doucet, D ;
Wickham, E ;
Atkins, D ;
Barker, D ;
Chee, M ;
Wang, YX ;
Fan, JB .
AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (05) :1799-1807
[9]   Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia [J].
Bullinger, L ;
Döhner, K ;
Bair, E ;
Fröhling, S ;
Schlenk, RF ;
Tibshirani, R ;
Döhner, H ;
Pollack, JR .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (16) :1605-1616
[10]   Post-analysis follow-up and validation of microarray experiments [J].
Chuaqui, RF ;
Bonner, RF ;
Best, CJM ;
Gillespie, JW ;
Flaig, MJ ;
Hewitt, SM ;
Phillips, JL ;
Krizman, DB ;
Tangrea, MA ;
Ahram, M ;
Linehan, WM ;
Knezevic, V ;
Emmert-Buck, MR .
NATURE GENETICS, 2002, 32 (Suppl 4) :509-514