Synthesis of New [12]aneN3 Compounds and Their Catalytic Cleavage of Phosphodiester

被引：0

作者：

Guo Zhi-Fo ^{[1
]}

Yan Hao ^{[1
]}

Li Zhi-Fen ^{[1
]}

Lu Zhong-Lin ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2011年 / 32卷 / 09期

关键词：

Artificial nuclease; Macrocyclic polyamine; Phosphodiester; Click reaction; Zinc(II) complex; ARTIFICIAL NUCLEASES; ZINC(II) COMPLEXES; DNA; RNA; PHOSPHATE; MODEL; ENZYMES; BINUCLEAR; CHEMISTRY; BINDING;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new methyl 3,5-dimethylbenzolate derived [12]aneN(3) compounds 4a and 4b were prepared through high efficient click reactions and characterized with element analysis, NMR, IR and high resolution MS. The corresponding zinc (II) complexes can greatly promote the cleavage of RNA model phosphodiester 2-hydroxypropyl-4-nitrophenylphosphate(HPNPP) in methanol with an acceleration of 10(7)-fold relative to the background reaction.

引用

页码：2128 / 2132

页数：5

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